Team:NYMU-Taipei/Project

From 2011.igem.org

(Difference between revisions)
(→Part 2)
Line 47: Line 47:
== '''Overall project''' ==
== '''Overall project''' ==
-
iD'Avatar, a safer bio-medical interface created by NYMU-Taipei team. In this year, we aim for developing a safer medical environment of optogenetics therapy. Optogenetics is the latest neuroscientific method breakthrough promised to take over electrode stimulation due to improved specificity for certain types of neurons, reversible bi-directional stimulation, and elevated spatial precision. However, to achieve neuronal network stimulation, light cables are still needed, which only substitutes the original steel electrodes, leaving long-standing annoying issues regarding immune responses unresolved. By the way, many countries haven’t established their own electronic medical records; thus, communication between doctors and doctors is really a tough problem. Furthermore, when you travel around the world, you may encounter the same problem that without a medical record, doctors may do a wrong decision which may cause exacerbations or even death. Two systems have been designed to solve the problems above: wireless neuro-stimulator and MRY labeling system.
+
Optogenetics, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved. This year NYMU-Taipei iGEM team creates wireless neuro-stimulator, focusing on achieving remote neuro-stimulation to minimize the invasion and damage to the neuron. To achieve this goal, we use a species of magnetic bacteria, Magnetospirillum magneticum AMB-1. We have chosen mms13, a transmembrane protein as our target for protein design, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we choose three genes to achieve symbiosis within glial cell: MinC, a division inhibitor, INV, a gene for invasion and LLO, a gene for facilitated escape from phagosomes. Overall, our project will make optogenetic neuro-stimulation wireless and safe.
-
(1) Wireless neuro-stimulator - focuses on achieving remote neuro-stimulation to minimize the invasion and damage to the brain tissue by using a species of magnetic bacteria, Magnetospirillum magneticum AMB-1. On the magnetosome membrane of AMB-1 locates a transmembrane protein, Mms13, which binds very tightly to the magnetite. And we have chosen it as our target for protein design as it serves as a linker between reception of magnetic field and signal transduction directly within biological systems. Furthermore, the aim to achieve intracerebral symbiosis is also highly stressed. (2) MRY labeling system- An efficient way to prevent medical negligence. MRY stands for Medical Record Yeast, which contains your medical records in a DNA encoded fashion, which can’t be easily decrypted. This design can prove your own privacy and information safety. Medical records yeasts which can be symbiotic with human skin are labeled on your upper arm. Doctors will do a quick screen to collect Medical records yeasts and use special DNA hybridization chip to decrypt the medical records and do the diagnosis properly. this system can help the medical records exchange between doctors and doctors, preventing information asymmetry happens in some countries without proper electronic medical records system or when having an emergency call in foreign hospitals.
+
== Project Details==
== Project Details==

Revision as of 16:44, 2 September 2011


This is a template page. READ THESE INSTRUCTIONS.
You are provided with this team page template with which to start the iGEM season. You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki. You can find some examples HERE.
You MUST have a team description page, a project abstract, a complete project description, a lab notebook, and a safety page. PLEASE keep all of your pages within your teams namespace.


You can write a background of your team here. Give us a background of your team, the members, etc. Or tell us more about something of your choosing.
File:NYMU-Taipei logo.png
200px

Tell us more about your project. Give us background. Use this is the abstract of your project. Be descriptive but concise (1-2 paragraphs)

File:NYMU-Taipei team.png
Your team picture
Team Example


Home Team Official Team Profile Project Parts Submitted to the Registry Modeling Notebook Safety Attributions



Contents

Overall project

Optogenetics, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved. This year NYMU-Taipei iGEM team creates wireless neuro-stimulator, focusing on achieving remote neuro-stimulation to minimize the invasion and damage to the neuron. To achieve this goal, we use a species of magnetic bacteria, Magnetospirillum magneticum AMB-1. We have chosen mms13, a transmembrane protein as our target for protein design, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we choose three genes to achieve symbiosis within glial cell: MinC, a division inhibitor, INV, a gene for invasion and LLO, a gene for facilitated escape from phagosomes. Overall, our project will make optogenetic neuro-stimulation wireless and safe.

Project Details

BLOC-MAGNETO: International Collaboration on de novo synthesis of pYMB and prospects discussions on the application of AMB-1

The Experiments

Part 3

Results

Retrieved from "http://2011.igem.org/Team:NYMU-Taipei/Project"