Team:WITS-CSIR SA

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Our Project Concept:
 
To genetically reprogram the chemotactic behaviour of E. coli, through the use of synthetic riboswitches. This will enable bacteria to search a defined area for a particular ligand and return to a set location (the starting point), where they can report on their findings.
To genetically reprogram the chemotactic behaviour of E. coli, through the use of synthetic riboswitches. This will enable bacteria to search a defined area for a particular ligand and return to a set location (the starting point), where they can report on their findings.
As a proof of principle, we want to test the ability of the reprogrammed cells to locate atrazine/theophylline on a petri-dish, and return to the initial point of departure for reporting. To do this we have three constructs that will make the bacteria toggle between two states of chemotactic responsiveness to different substances.</p>
As a proof of principle, we want to test the ability of the reprogrammed cells to locate atrazine/theophylline on a petri-dish, and return to the initial point of departure for reporting. To do this we have three constructs that will make the bacteria toggle between two states of chemotactic responsiveness to different substances.</p>

Revision as of 10:57, 23 May 2011

Our Project Concept

To genetically reprogram the chemotactic behaviour of E. coli, through the use of synthetic riboswitches. This will enable bacteria to search a defined area for a particular ligand and return to a set location (the starting point), where they can report on their findings. As a proof of principle, we want to test the ability of the reprogrammed cells to locate atrazine/theophylline on a petri-dish, and return to the initial point of departure for reporting. To do this we have three constructs that will make the bacteria toggle between two states of chemotactic responsiveness to different substances.
This dude has some chalk. Mostly I don't have any content to put here.
This is the same thing as the last...
A board ... with writing.
Reading something.
Boomerang Bacteria
We have decided on a project manipulating bacterial chemotaxis. What is chemotaxis? Well, it's the ability of bacteria to swim towards something they're attracted to and swim away from chemicals that are potentially dangerous to them. We will be engineering bacteria to be attracted to a substance, reach the source of that substance and once they are there, turn off their attraction to this substance and become attracted to another substance. This means we can send a bacteria out to detect something. Once it's found its highest concentration, it will swim back to the start to report back. This project has potential applications in mining, medicine and water treatment!
Meet the team
The CSIR Wits South Africa team consists of six enthusiastic undergraduate students each having their own area of expertise. Four of the members are studying science and two are studying engineering at the University of the Witwatersrand. The biologists are from the schools of Molecular and Cell Biology and Molecular Medicine and Hematology. The team has two engineering students, one studying information engineering and the other, chemical engineering. This team is a dynamic one where each team member has something unique to offer to the competition.
Software
We created the following software during the competition.



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