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Team:NYMU-Taipei
From 2011.igem.org
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==<font size=5><font color=crimson>'''Tailoring Your Avatar'''</font></font>== | ==<font size=5><font color=crimson>'''Tailoring Your Avatar'''</font></font>== | ||
| - | '''<font size=4><font color=green> | + | '''<font size=4><font color=green>Goal</font>''' |
<font size=3>Create wireless neuro-stimulator, focusing on achieving remote neuro-stimulation to minimize the invasion and damage to the neuron.</font> | <font size=3>Create wireless neuro-stimulator, focusing on achieving remote neuro-stimulation to minimize the invasion and damage to the neuron.</font> | ||
| - | '''<font size=4><font color=green> | + | '''<font size=4><font color=green>Why do we want to do that?</font> |
<font size=3>Optogenetics, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved. </font> | <font size=3>Optogenetics, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved. </font> | ||
| - | '''<font size=4><font color=green> | + | '''<font size=4><font color=green>Specific aims</font>''' |
<font size=4><font color=blue>'''(i) Wireless stimulation for neurons'''</font></font> | <font size=4><font color=blue>'''(i) Wireless stimulation for neurons'''</font></font> | ||
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| - | '''<font size=4><font color=green> | + | '''<font size=4><font color=green>Our design</font>''' |
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To achieve this goal, we use a species of magnetic bacteria,'' Magnetospirillum magneticum'' AMB-1. We have chosen <b>mms13</b>, a transmembrane protein as our target for protein design in this bacterium, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we utilized three genes to achieve neurosymbiosis within glial cells: ''MinC'', a division inhibitor, ''INV'', a gene for invasion and ''LLO'', a gene for facilitated escaping from phagosomes.</font> | To achieve this goal, we use a species of magnetic bacteria,'' Magnetospirillum magneticum'' AMB-1. We have chosen <b>mms13</b>, a transmembrane protein as our target for protein design in this bacterium, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we utilized three genes to achieve neurosymbiosis within glial cells: ''MinC'', a division inhibitor, ''INV'', a gene for invasion and ''LLO'', a gene for facilitated escaping from phagosomes.</font> | ||
| - | '''<font size=3>Our design is made up of the following two devices:</font>''' | + | '''<font size=3>Our design is made up of the following two devices:</font>''' |
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<font size=3> | <font size=3> | ||
*[https://2011.igem.org/Team:NYMU-Taipei/optomagnetic-design Optomagnetic Design] | *[https://2011.igem.org/Team:NYMU-Taipei/optomagnetic-design Optomagnetic Design] | ||
Revision as of 19:42, 28 October 2011
Tailoring Your AvatarGoal Create wireless neuro-stimulator, focusing on achieving remote neuro-stimulation to minimize the invasion and damage to the neuron. Why do we want to do that? Optogenetics, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved. Specific aims (i) Wireless stimulation for neurons (ii) Minimize neuro-immuno response Our design
To achieve this goal, we use a species of magnetic bacteria, Magnetospirillum magneticum AMB-1. We have chosen mms13, a transmembrane protein as our target for protein design in this bacterium, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we utilized three genes to achieve neurosymbiosis within glial cells: MinC, a division inhibitor, INV, a gene for invasion and LLO, a gene for facilitated escaping from phagosomes. Our design is made up of the following two devices:
 File:Https://static.igem.org/mediawiki/2011/3/33/End.png 
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