Team:NYMU-Taipei
From 2011.igem.org
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==<font size=5><font color=crimson>'''Tailoring Your Avatar'''</font></font>== | ==<font size=5><font color=crimson>'''Tailoring Your Avatar'''</font></font>== | ||
'''<font size=4><font color=green>(i) Goal</font>''' | '''<font size=4><font color=green>(i) Goal</font>''' | ||
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** [http://issue.ym.edu.tw/cia/new/tw/ym720.html Take a tour of our university] | ** [http://issue.ym.edu.tw/cia/new/tw/ym720.html Take a tour of our university] | ||
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Revision as of 19:36, 28 October 2011
Tailoring Your Avatar(i) Goal Create wireless neuro-stimulator, focusing on achieving remote neuro-stimulation to minimize the invasion and damage to the neuron. (ii) Why do we want to do that? Optogenetics, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved. (iii) Specific aims Wireless stimulation for neurons Minimize neuro-immuno response
To achieve this goal, we use a species of magnetic bacteria, Magnetospirillum magneticum AMB-1. We have chosen mms13, a transmembrane protein as our target for protein design in this bacterium, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we choose three genes to achieve symbiosis within glial cell: MinC, a division inhibitor, INV, a gene for invasion and LLO, a gene for facilitated escape from phagosomes.
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