"
Team:NYMU-Taipei
From 2011.igem.org
| Line 7: | Line 7: | ||
<font size=5>'''Tailoring Your Avatar'''</font><br> | <font size=5>'''Tailoring Your Avatar'''</font><br> | ||
<br> | <br> | ||
| - | *'''<font size=3>Goal</font>'''<br> | + | * '''<font size=3>Goal</font>'''<br> |
<font size=2>creates wireless neuro-stimulator, focusing on achieving remote neuro-stimulation to minimize the invasion and damage to the neuron</font> | <font size=2>creates wireless neuro-stimulator, focusing on achieving remote neuro-stimulation to minimize the invasion and damage to the neuron</font> | ||
| - | *'''<font size=3>Why do we want to do that?</font><br> | + | * '''<font size=3>Why do we want to do that?</font><br> |
<font size=2>Optogenetics, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved. </font> | <font size=2>Optogenetics, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved. </font> | ||
| + | * '''<font size=3>Specific aims</font>'''<br> | ||
| + | <font size=2> | ||
| + | ** 1. Wireless stimulate neuron | ||
| + | ** 2. Minimize neuro-immuresponse | ||
| + | </font> | ||
------------------------------------------------------------- | ------------------------------------------------------------- | ||
Revision as of 12:53, 5 October 2011
|
Tailoring Your Avatar
creates wireless neuro-stimulator, focusing on achieving remote neuro-stimulation to minimize the invasion and damage to the neuron
Optogenetics, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved.
|
To achieve this goal, we use a species of magnetic bacteria, Magnetospirillum magneticum AMB-1. We have chosen mms13, a transmembrane protein as our target for protein design in this bacterium, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we choose three genes to achieve symbiosis within glial cell: MinC, a division inhibitor, INV, a gene for invasion and LLO, a gene for facilitated escape from phagosomes.
|
SPONSORED BY
