Team:Wageningen UR/Project/ModelingProj1
From 2011.igem.org
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'''Fig.1:''' ''Basic oscillating genetic circuit as published by Danino & Hasty.'' | '''Fig.1:''' ''Basic oscillating genetic circuit as published by Danino & Hasty.'' | ||
- | The genes luxI and aiiA can be expressed when a AHL-LuxR complex binds to the promoter region. The circuit uses both a positive and negative feedback loop to control the AHL concentration and therefore the expression of the resulting proteins LuxI and AiiA. In the positive loop, LuxI generates more AHL, which, together with LuxR, can form more of the activating AHL-LuxR complex and therefore stimulates even more production of LuxI and consequently AHL. This complex also activates the expression of aiiA. In the negative feedback loop, AiiA degrades the AHL produced. For more detailed information about the circuit [[Team:Wageningen_UR/Project/CompleteProject1Description | + | The genes luxI and aiiA can be expressed when a AHL-LuxR complex binds to the promoter region. The circuit uses both a positive and negative feedback loop to control the AHL concentration and therefore the expression of the resulting proteins LuxI and AiiA. In the positive loop, LuxI generates more AHL, which, together with LuxR, can form more of the activating AHL-LuxR complex and therefore stimulates even more production of LuxI and consequently AHL. This complex also activates the expression of aiiA. In the negative feedback loop, AiiA degrades the AHL produced. For more detailed information about the circuit [[Team:Wageningen_UR/Project/CompleteProject1Description#2._Mechanism| read more here.]] |
Revision as of 21:51, 11 September 2011