Team:Valencia/Modeling

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     <li><a href="https://2010.igem.org/Team:Valencia">Casa</a>
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     <li><a href="https://2011.igem.org/Team:Valencia">Home</a>
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             <a href="https://2010.igem.org/Team:Valencia">Bea</a> |
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             <a href="https://2010.igem.org/Team:Valencia">Team</a> |
             <a href="https://2010.igem.org/Team:Valencia#The Valencia IGEM Team 2010">The Valencia Team</a> |
             <a href="https://2010.igem.org/Team:Valencia#The Valencia IGEM Team 2010">The Valencia Team</a> |
             <a href="https://2010.igem.org/Team:Valencia#News">News</a>
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         <a href="https://2010.igem.org/Team:Valencia/Team">The Team</a>
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             <a href="https://2010.igem.org/Team:Valencia/Project">Overview</a> |
             <a href="https://2010.igem.org/Team:Valencia/Project">Overview</a> |
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             <a href="https://2010.igem.org/Team:Valencia/Terraforming">Terraforming</a> |
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             <a href="https://2010.igem.org/Team:Valencia/Terraforming">Project 1</a> |
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             <a href="https://2010.igem.org/Team:Valencia/Technologies">Creating Technologies</a> |
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             <a href="https://2010.igem.org/Team:Valencia/Technologies">Project 2</a> |
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             <a href="https://2010.igem.org/Team:Valencia/lea">Surviving Mars</a> |
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             <a href="https://2010.igem.org/Team:Valencia/lea">Project 3</a> |
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             <a href="https://2010.igem.org/Team:Valencia/prion">Regulating Mars temperature</a>
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             <a href="https://2010.igem.org/Team:Valencia/prion">Project 4</a>
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         <a href="https://2010.igem.org/Team:Valencia/Parts">The Parts</a>
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         <a href="https://2011.igem.org/Team:Valencia/Parts">The Parts</a>
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         <a href="https://2010.igem.org/Team:Valencia/Modeling">Modeling</a>
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         <a href="https://2011.igem.org/Team:Valencia/Modeling">Modeling</a>
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             <a href="https://2010.igem.org/Team:Valencia/Modeling">Modeling Mad Yeast On Mars</a>|
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             <a href="https://2010.igem.org/Team:Valencia/Modeling">Modeling 1</a>|
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             <a href="https://2010.igem.org/Team:Valencia/Modeling#Welcome to the Yeastworld: theoretical background ">Yeastworld: theoretical background</a>|
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            <a href="https://2010.igem.org/Team:Valencia/Modeling#Yeastworld Mathematics">Yeastworld Mathematics</a>
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<p>Mad yeasts on Mars?
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<p>Biodesinfector (e.g)
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<p>Under this curious title it is hidden the ambitious Project of Valencia iGEM team. In our project, we intend to present an intermediate scenario in the pathway towards the <a href="/Team:Valencia/Terraforming" title="Team:Valencia/Terraforming"> terraforming of Mars</a> (i. e., modifying the atmosphere and temperature of Mars in order to get the appropriate conditions to make it habitable for Terran living organisms). The idea is that, after preliminary changes devoted to make Mars conditions more suitable for life, it can be colonized by microorganisms that will accelerate some changes to make the planet conditions acceptable for plant life which, then, will be able to generate enough oxygen to eventually allow the colonization by animals, including humans.  
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<p>The aim of our team is to develop a biological alternative for disinfecting contaminated water using synthetic biology. We will kill targeted pathogens by means of antimicrobial peptides in Escherichia coli. The activity of these proteins will be controlled by a biological pH-stat that will use cyanobacteria to control pH.
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We plan to deliver a DIY kit that will help people that struggle to find pathogen-free drinking water avoiding important diseases, such as cholera, diarrhea and typhoid fever, ending in more than 2 million deaths in the last year according to the WHO Guidelines for Drinking-Water Quality (World Health Organization, 2011).  
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<a href="/Image:Valencia_MarsTransition.jpg" class="image" title="Valencia MarsTransition.jpg"><img alt="" src="/wiki/images/thumb/4/41/Valencia_MarsTransition.jpg/690px-Valencia_MarsTransition.jpg" width="690" height="174" border="0" /></a>
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<a href="/images/3/32/Albuferavalencia.jpg" class="image" title="Valencia MarsTransition.jpg"><img alt="" src="/wiki/images/3/32/Albuferavalencia.jpg" width="690" height="300" border="0" /></a>
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</p><p>Obviously, we do not pretend to follow up all the process, but just to focus on the microorganisms’ colonization step, as motors of the atmosphere building and heating, two essential conditions on the Terraformation process.
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</p><p>T.1
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</p><p>A consequence of the low Martian atmospheric density, the global temperature on Mars depends mainly on the energy exchange between the planet surface and the solar radiation. Therefore, one way to increase the temperature of the planet would be the change of the albedo altering the color of the surface and making it darker.
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</p><p>T.2
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<a href="/Team:Valencia/Project" title="Team:Valencia/Project"> Our proposal</a> is that dark yeast cells would retain the arriving solar radiation and heat the surface. But, once the temperature reaches its optimum on the planetary surface, dark cells will no more be necessary and the color production should be switched off. In order to achieve that and taking advantage of Synthetic Biology principles, a <a href="/Team:Valencia/prion" title="Team:Valencia/prion"> switch based on prion proteins</a> (on mad yeast!) will be used. 
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</p><p>T.3
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</p><p>On the other hand, a big deal with this approach is the resistance of the organism to violent thermal changes of the Martian surface (summer-winter, day-night) which under certain conditions can be in a range of 20ºC and -80ºC. Thus this work will be complemented with the implementation of the expression of a <a href="/Team:Valencia/lea" title="Team:Valencia/lea"> LEA (Late Embryogenesis Abundant) “antifreeze” protein</a>. These proteins in both plants and animals are associated with tolerance to water stress resulting from desiccation and cold shock.
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</p><p>T.4
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</p><p>Summarizing, we are going to build a engineered yeast resistant to temperature changes and able to produce a dark pigment which will be the responsible of a global temperature increase on Mars.
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<a name="The_Valencia_IGEM_Team_2010"></a><h1> <span class="mw-headline">The Valencia IGEM Team 2010</span></h1>
<a name="The_Valencia_IGEM_Team_2010"></a><h1> <span class="mw-headline">The Valencia IGEM Team 2010</span></h1>
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<div class="floatright"><span><a href="/Image:Valencia_logo_loco_200.png" class="image" title="Valencia logo loco 200.png"><img alt="" src="/wiki/images/thumb/7/7f/Valencia_logo_loco_200.png/180px-Valencia_logo_loco_200.png" width="180" height="177" border="0" /></a></span></div>
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<div class="floatright"><span><a href="/Image:Valencia_logo_loco_200.png" class="image" title="Valencia logo loco 200.png"><img alt="" src="/wiki/images/thumb/7/7f/Valencia_logo_loco_200.png/180px-Valencia_logo_loco_200.png" width="50" height="50" border="0" /></a></span></div>
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<p>We have the 2010 IGEM team: 9 students from both Universitat de València and Universidad Politècnica de València, go to <a href="/Team:Valencia/Universities" title="Team:Valencia/Universities">The Universities</a>. Most of us have backgrounds in Biology, Biotechnology, Chemistry, Engineering and Computer Sciences. We want to discover the enigmas of Synthetic Biology and now also the ones tha Mars puts on the table!!!! Go to <a href="/Team:Valencia/Team" title="Team:Valencia/Team">The Team</a>  page for more info on us. In the <a href="/Team:Valencia/Notebook/Calender" title="Team:Valencia/Notebook/Calender">Notebook</a> you can follow up our work in progress!!! and in <a href="/Team:Valencia/Gallery" title="Team:Valencia/Gallery">Gallery</a> you can see a bunch of pictures of the team working.
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<p>T.6
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<a name="News"></a><h1> <span class="mw-headline">News</span></h1>
<a name="News"></a><h1> <span class="mw-headline">News</span></h1>
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<div class="floatright"><span><a href="/Image:Valencia_nasa.jpg" class="image" title="NASA"><img alt="NASA" src="/wiki/images/thumb/a/a1/Valencia_nasa.jpg/140px-Valencia_nasa.jpg" width="140" height="120" border="0" /></a></span></div>
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<div class="floatright"><span><a href="/Image:Valencia_nasa.jpg" class="image" title="NASA"><img alt="NASA" src="/wiki/images/thumb/a/a1/Valencia_nasa.jpg/140px-Valencia_nasa.jpg" width="50" height="50" border="0" /></a></span></div>
<ul><li>02/11/2011 - Meeting with David Bergner, Deputy Chief of the <a href="http://spacebiosciences.arc.nasa.gov/" class="external text" title="http://spacebiosciences.arc.nasa.gov/" rel="nofollow">Division of Space Biosciences</a>, from <a href="http://www.nasa.gov/centers/ames/home/index.html" class="external text" title="http://www.nasa.gov/centers/ames/home/index.html" rel="nofollow">NASA Ames Research Center</a>. Discussed synthetic biology application in space bioscience.  
<ul><li>02/11/2011 - Meeting with David Bergner, Deputy Chief of the <a href="http://spacebiosciences.arc.nasa.gov/" class="external text" title="http://spacebiosciences.arc.nasa.gov/" rel="nofollow">Division of Space Biosciences</a>, from <a href="http://www.nasa.gov/centers/ames/home/index.html" class="external text" title="http://www.nasa.gov/centers/ames/home/index.html" rel="nofollow">NASA Ames Research Center</a>. Discussed synthetic biology application in space bioscience.  
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<div class="floatleft"><span><a href="/Image:Valencia_jamboree.jpg" class="image" title="Jamboree 2010"><img alt="Jamboree 2010" src="/wiki/images/thumb/b/b1/Valencia_jamboree.jpg/200px-Valencia_jamboree.jpg" width="200" height="133" border="0" /></a></span></div>
<div class="floatleft"><span><a href="/Image:Valencia_jamboree.jpg" class="image" title="Jamboree 2010"><img alt="Jamboree 2010" src="/wiki/images/thumb/b/b1/Valencia_jamboree.jpg/200px-Valencia_jamboree.jpg" width="200" height="133" border="0" /></a></span></div>
<p><b>Jamboree 2010 Highlights</b>
<p><b>Jamboree 2010 Highlights</b>
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</p><p><a href="/Image:Valencia_gold_medal.jpg" class="image" title="Image:valencia_gold medal.jpg"><img alt="Image:valencia_gold medal.jpg" src="/wiki/images/4/44/Valencia_gold_medal.jpg" width="367" height="36" border="0" /></a>
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</p><p><a href="/Image:Valencia_gold_medal.jpg" class="image" title="Image:valencia_gold medal.jpg"><img alt="Image:valencia_gold medal.jpg" src="/wiki/images/4/44/Valencia_gold_medal.jpg" width="50" height="30" border="0" /></a>
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<ul><li>Gold Medal: Received a gold medal for the BioBricks we made and characterized, our human practice, our modeling  efforts, our Experimental mesurements and our great project!!!.
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<ul><li>T.7
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<div class="floatright"><span><a href="/Image:Valencia_nota_publico.jpg" class="image" title="IGEM Valencia team 2010 project explained"><img alt="IGEM Valencia team 2010 project explained" src="/wiki/images/thumb/c/c4/Valencia_nota_publico.jpg/200px-Valencia_nota_publico.jpg" width="200" height="153" border="0" /></a></span></div>
<div class="floatright"><span><a href="/Image:Valencia_nota_publico.jpg" class="image" title="IGEM Valencia team 2010 project explained"><img alt="IGEM Valencia team 2010 project explained" src="/wiki/images/thumb/c/c4/Valencia_nota_publico.jpg/200px-Valencia_nota_publico.jpg" width="200" height="153" border="0" /></a></span></div>
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<p>We are on the national news!!! Check out the article "Synthetic bacteria for Mars" (in spanish in the <i>Publico</i> news paper on Sunday May 23th).
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<p>T.8
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</p><p>The article reviews the last year project of the Valencia IGEM 2009 team and then explains this year project.
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Revision as of 11:39, 30 August 2011

Team:Valencia - 2010.igem.org

Team:Valencia

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Biodesinfector (e.g)

The aim of our team is to develop a biological alternative for disinfecting contaminated water using synthetic biology. We will kill targeted pathogens by means of antimicrobial peptides in Escherichia coli. The activity of these proteins will be controlled by a biological pH-stat that will use cyanobacteria to control pH. We plan to deliver a DIY kit that will help people that struggle to find pathogen-free drinking water avoiding important diseases, such as cholera, diarrhea and typhoid fever, ending in more than 2 million deaths in the last year according to the WHO Guidelines for Drinking-Water Quality (World Health Organization, 2011).



T.1

T.2

T.3

T.4

The Valencia IGEM Team 2010

T.6

News

NASA




Jamboree 2010

Jamboree 2010 Highlights

Image:valencia_gold medal.jpg

  • T.7




Valencia Team in the News

IGEM Valencia team 2010 project explained

T.8

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