Biological signals control all life processes within and between cells. These signals are regulated in a dynamic and complex way that is hard to study with present techniques. It is the goal of BIOSS to change this by developing a new research strategy that allows a better study of signalling events and may solve many open questions in the field of biological and medical signalling research.
The scientists participating in this Cluster of Excellence not only apply modern analytical methods and combine they also combine these with new synthetic procedures. This not only allows them to better understand biological signalling systems, but also allows reconstruction and controlling of part of these systems in a creative and unconventional way. The design of new types of molecules which can function as signal switches or detectors opens new horizons in research and applications.
Inspired by the motto ‘from analysis to synthesis’, BIOSS continues to advance the field of synthetic biology and to make it more applicable to signalling research. BIOSS plans to develop innovative therapeutic approaches in its new research foci: deregulated signalling in tumour cells and signal processes in and at membranes.
|
|
SERVA Electrophoresis GmbH /Heidelberg (Germany)
For almost 60 years SERVA Electrophoresis GmbH
offers products of prime quality to the Life Sciences
research market, like albumins, antibiotics, buffers,
collagenases, dyes, enzymes and enzyme inhibitors,
ion exchange media, proteins, surfactants and more.
As special services SERVA offers bulk packaging and
customizing of products, e. g. biological buffers, precast
gels.
In a leading position in electrophoresis, SERVA
Electrophoresis GmbH recently released new products
for the proteome research community, e. g. HPE FlatTop
Tower, SERVA IPG BlueStrips, large-sized precast
gels for horizontal 2D gel electrophoresis, SERVAGelTM
precast vertical mini gels and the SERVA ICPLTM-Kit for
quantification of proteins by mass spectrometry.
In tissue engineering SERVA offers Collagenase NB
for the isolation of different cell types. Where medical
applications require a particular quality SERVA offers
Collagenase NB manufactured according to GMP
guidelines (e.g. Collagenase NB 1 GMP Grade).
SERVA Electrophoresis GmbH is a mid-sized,
European-based company supplying high quality life
sciences reagents to its customers, worldwide. |
|
BMG LABTECH, the Microplate Reader Company based in Germany, is a leading developer and global manufacturer of microplate reader instrumentation. BMG LABTECH offers multidetection microplate reader platforms for fluorescence intensity, luminescence (DLReadyTM), fluorescence polarization, absorbance, time-resolved fluorescence, and AlphaScreen®/AlphaLISA® measurements. Proven assays include HTRF®, LanthaScreenTM, Lance®, hERG-PredictorTM, ADP2-Transcreener®, and laser-based nephelometry for compound solubility screening. For more information please visit www.bmglabtech.com.
|
|
Eurofins MWG Operon has major offices and production facilities in Europe, the United
States, and Asia, and is an international provider of DNA sequencing services, DNA
synthesis products and bioinformatic services for academic and industrial research. As one
of the first service providers for next generation sequencing, Eurofins MWG Operon has
established profound know-how and proprietary protocols to cover a broad range of
applications. The company’s strength is its strong customer orientation, fast service, and high
quality. For further information, please visit our website www.eurofinsdna.com.
|
|
GATC Biotech is Europe’s leading service provider of DNA sequencing and bioinformatics for industry and academic research. For two decades the company has been developing sequencing and bioinformatics solutions from individual samples, transcriptomes and regulomes, up to whole genomes. GATC Biotech offers multiplatform sequencing using all leading sequencing technologies: ABI 3730xl, Roche GSFLX+ System, Illumina Genome Analyzer IIx and HiSeq 2000. With the PACBio RS from Pacific Biosciences, a sequencing technology of the third generation has recently been installed. GATC Biotech has Europe’s largest commercially available sequencing platform, beeing ISO-certified since 1999 and an Illumina CSPro certified service provider.
Headquartered in Konstanz, Germany, the company serves over 10,000 customers worldwide with more than 140 employees and subsidiary companies in Great Britain, France and Sweden.
|
![](https://static.igem.org/mediawiki/2011/f/f4/Freiburg2011_GATC_Logo.gif) |
ATG:biosynthetics is your partner for planning, design, operation and control of
“INTEGRATIVE BIOTECH PROJECTS" with high impact on NEW MARKETS for BIOECONOMY.
We are on a strong technological basis in SYNTHETIC BIOLOGY focusing on synthetic genes, gene
and gene cluster designs, multi-protein-expression and bio-molecule separation technologies.
(1) ATG:biosynthetics uses computational methods based on the proprietary evoMAG software package.
Optimal functional DNA sequence features of genes mostly are conflicting in target functions.
RNA secondary structures for translational initiation process and the genetic code for elongation
leave sufficient space for multi-parametric gene feature calculations which allow multiple
compromise solutions which are weighted and directed to target gene function.
Genetic algorithms for parallel optimization of multiple sequence features are applied.
We help making gene expression more reliable by avoiding malfunction.
(2) ATG’s Synthetic Biology “Application Builder” tools is online available as a design tool
for setting up customer projects and providing genetic building blocks libraries.
In metabolic engineering, the DNA can be designed to produce small molecule drugs
such as Epothilones (small molecules which are potential anti-cancer drugs) similar to
paradigm Artemisinin (a drug used to treat multi-drug resistant malaria).
ATG at present is involved in pathway designs for Polyketides and Mevalonate paths and others…
(3) With the ACEMBL - technology ATG is focused on “Multiple Gene/ Protein Expression Systems”
Multiple gene expression is available for E. coli, Baculovirus infected Insect cells and for Mammalian systems.
ACEMBL CLASSIC can be adapted for many more organisms. TOGGLE –ACEMBL allows the assembly of
many expression cassettes for the design of pathways and protein complex structures.
(4) Purification of bio-molecules can easily be performed with the MONOLITH - technology in
industrial scales. The advantages of MONOTITH are in separation speed increase due
to higher insensivity towards higher pressure compared to other technology
thus SAVING TIME and MONEY.
|
![](https://static.igem.org/mediawiki/2011/d/df/Freiburg2011_LOGO_ATG_YPSB-CourierNew.jpg) |
Life Technologies is a global biotechnology tools company dedicated to improving the human condition. Our systems, consumables and services enable researchers to accelerate scientific exploration, driving to discoveries and developments that make life even better. Life Technologies customers do their work across the biological spectrum, working to advance personalized medicine, regenerative science, molecular diagnostics, agricultural and environmental research, and 21st century forensics. Life Technologies was created by the combination of Invitrogen Corporation and Applied Biosystems Inc. For more information on how we are making a difference please visit our website: www.lifetechnologies.com.
|
![](https://static.igem.org/mediawiki/2011/0/03/Freiburg2011_Sponsoring_LifeTechnologies_Logo_RGB_022309.png) |
|
|