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| - | <!-- *** What falls between these lines is the Alert Box! You can remove it from your pages once you have read and understood the alert *** --> | + | <div id="header">{{Template:SouthBend-Mishawaka-HS/Templates/Header}}</div> |
| | + | === Welcome to === |
| | + | = "The DNA Architects of South Bend & Mishawaka" iGEM Team Wiki! = |
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| - | <html>
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| - | <div id="box" style="width: 700px; margin-left: 137px; padding: 5px; border: 3px solid #000; background-color: #fe2b33;">
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| - | <div id="template" style="text-align: center; font-weight: bold; font-size: large; color: #f6f6f6; padding: 5px;">
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| - | This is a template page. READ THESE INSTRUCTIONS.
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| - | </div>
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| - | <div id="instructions" style="text-align: center; font-weight: normal; font-size: small; color: #f6f6f6; padding: 5px;">
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| - | You are provided with this team page template with which to start the iGEM season. You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki. You can find some examples <a href="https://2009.igem.org/Help:Template/Examples">HERE</a>.
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| - | </div>
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| - | <div id="warning" style="text-align: center; font-weight: bold; font-size: small; color: #f6f6f6; padding: 5px;">
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| - | You <strong>MUST</strong> have a team description page, a project abstract, a complete project description, a lab notebook, and a safety page. PLEASE keep all of your pages within your teams namespace.
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| - | </div>
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| - | </div>
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| - | </html>
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| - | <!-- *** End of the alert box *** -->
| + | == Introduction: problem == |
| | | | |
| | + | * We have yet to define our problem but we are working on it!<br /><br /> |
| | | | |
| | + | == Primary Objective:== |
| | | | |
| - | {|align="justify"
| + | * We will have a primary objective once we settle on a problem. |
| - | |You can write a background of your team here. Give us a background of your team, the members, etc. Or tell us more about something of your choosing.
| + | == Secondary Objective:== |
| - | |[[Image:SouthBend-Mishawaka-HS_logo.png|200px|right|frame]]
| + | |
| - | |-
| + | |
| - | |
| + | |
| - | ''Tell us more about your project. Give us background. Use this as the abstract of your project. Be descriptive but concise (1-2 paragraphs)''
| + | |
| - | |[[Image:SouthBend-Mishawaka-HS_team.png|right|frame|Your team picture]]
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| - | |-
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| - | |
| + | |
| - | |align="center"|[[Team:SouthBend-Mishawaka-HS | Team Example]]
| + | |
| - | |}
| + | |
| | | | |
| - | <!--- The Mission, Experiments --->
| + | * We may have a secondary objective, but that depends upon our primary objective and that depends upon our problem... |
| | | | |
| - | {| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center"
| + | == Further Considerations == |
| - | !align="center"|[[Team:SouthBend-Mishawaka-HS|Home]]
| + | |
| - | !align="center"|[[Team:SouthBend-Mishawaka-HS/Team|Team]]
| + | |
| - | !align="center"|[https://igem.org/Team.cgi?year=2011&team_name=SouthBend-Mishawaka-HS Official Team Profile]
| + | |
| - | !align="center"|[[Team:SouthBend-Mishawaka-HS/Project|Project]]
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| - | !align="center"|[[Team:SouthBend-Mishawaka-HS/Parts|Parts Submitted to the Registry]]
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| - | !align="center"|[[Team:SouthBend-Mishawaka-HS/Modeling|Modeling]]
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| - | !align="center"|[[Team:SouthBend-Mishawaka-HS/Notebook|Notebook]]
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| - | !align="center"|[[Team:SouthBend-Mishawaka-HS/Safety|Safety]]
| + | |
| - | !align="center"|[[Team:SouthBend-Mishawaka-HS/Attributions|Attributions]]
| + | |
| - | |}
| + | |
| - | <!-- [[Image:NYMU_banner 000.png|700px]]-->
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| - | <!--[[Image:MainCartoon.png|border|center|Bac2Kidney]]-->
| + | * We aren't yet considering anything further than where we are in the process....stay tuned! |
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| - | <dl id="cartoonmap">
| + | |
| - | <dt>Banner</dt>
| + | |
| - | <dd id="banner">
| + | |
| - | <span><img src="/wiki/images/9/93/NYMU_Bannerinpic_700px.png" width="700" alt="BacToKidney - Toward a better quality of life"></span>
| + | |
| - | </dd>
| + | |
| - | | + | |
| - | <dt>pH Sensor</dt>
| + | |
| - | <dd id="ph"><a href="./Team:NYMU-Taipei/Project/pH_Sensor" onmouseover="haxbackground();" onmouseout="unhaxbackground();">
| + | |
| - | <span><div class="first">pH Sensor</div>
| + | |
| - | <div class="rest">A sensor of proton concentration (pH). Activates in a high pH environment.</div></span>
| + | |
| - | </a></dd>
| + | |
| - | | + | |
| - | <dt>Attachment</dt>
| + | |
| - | <dd id="at"><a href="./Team:NYMU-Taipei/Project/Attachment" onmouseover="haxbackground();" onmouseout="unhaxbackground();">
| + | |
| - | <span><div class="first">Attachment</div>
| + | |
| - | <div class="rest">Attachment to the small intestine.</div></span>
| + | |
| - | </a></dd>
| + | |
| - | | + | |
| - | <dt>Urea</dt>
| + | |
| - | <dd id="u"><a href="./Team:NYMU-Taipei/Project/Urea" onmouseover="haxbackground();" onmouseout="unhaxbackground();">
| + | |
| - | <span><div class="first">Clearance of Urea</div>
| + | |
| - | <div class="rest">A Urea clearance device.</div></span>
| + | |
| - | </a></dd>
| + | |
| - | | + | |
| - | <dt>Guanidine</dt>
| + | |
| - | <dd id="g"><a href="./Team:NYMU-Taipei/Project/Guanidine" onmouseover="haxbackground();" onmouseout="unhaxbackground();">
| + | |
| - | <span><div class="first">Clearance of Guanidine</div>
| + | |
| - | <div class="rest">The device managing the clearance of guanidino compounds.</div></span>
| + | |
| - | </a></dd>
| + | |
| - | | + | |
| - | <dt>Phosphate</dt>
| + | |
| - | <dd id="p"><a href="./Team:NYMU-Taipei/Project/Phosphate" onmouseover="haxbackground();" onmouseout="unhaxbackground();">
| + | |
| - | <span><div class="first">Clearance of Phosphate</div>
| + | |
| - | <div class="rest">A Phosphate clearance and balance device.</div></span>
| + | |
| - | </a></dd>
| + | |
| - | | + | |
| - | <dt>Time Regulation</dt>
| + | |
| - | <dd id="time"><a href="./Team:NYMU-Taipei/Project/Time_Regulation" onmouseover="haxbackground();" onmouseout="unhaxbackground();">
| + | |
| - | <span><div class="first">Time Regulation</div>
| + | |
| - | <div class="rest">Using oscillators to measure time, it enables detachment from the small intestine after a certain amount of time.</div></span>
| + | |
| - | </a></dd>
| + | |
| - | </dl>
| + | |
| - | </html>
| + | |
| - | {{:Team:NYMU-Taipei/Links}}
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| - | {| style="width:965px;border:1px solid gray;"
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| - | |-
| + | |
| - | | style="vertical-align:top;width:50%;border-right:1px solid gray;" | <font size="4"><b>'''BacToKidney'''</b></font> - ''Toward a better quality of life''.
| + | |
| - | <br>'''Goal:'''
| + | |
| - | *Use designer bacteria to replace a hemodialysis machine to remove (filter out) toxic waste for treating kidney failure.
| + | |
| - | <br>'''Why is it an interesting problem?'''
| + | |
| - | * Approximately 1.3 million people globally have chronic kidney failure that requires either renal transplantation or dialysis - for such patients, the established treatment is hemodialysis
| + | |
| - | * The mortality rate of patients undergoing maintenance hemodialysis remains unacceptably high.
| + | |
| - | * An extremely high morbidity and a relatively low quality of life (due in part to a high level of dependence and unemployment) and high cost have also been observed.
| + | |
| - | <br>'''Our Design:'''
| + | |
| - | * After ingesting our BacToKidney capsule, it passes the through stomach without taking any action, nor being digested, and proceeds to the small intestine. Once in the small intestine, the [[Team:NYMU-Taipei/Project/pH Sensor|pH Sensor]] detects the change in pH and activates the clearance processes of [[Team:NYMU-Taipei/Project/Urea|Urea]], [[Team:NYMU-Taipei/Project/Phosphate|Phosphate]], and [[Team:NYMU-Taipei/Project/Guanidine|Guanidine]] from the body. To allow itself more time to perform its tasks, the [[Team:NYMU-Taipei/Project/pH Sensor|pH Sensor]] also activates the [[Team:NYMU-Taipei/Project/Attachment|Attachment]] process, making the capsule attach itself to the small intestine. After a pre-selected amount of time has passed (controlled by the [[Team:NYMU-Taipei/Project/Time Regulation|time regulating oscillators]]), the capsule detaches itself from the small intestine and exits the body.
| + | |
| - | <br>'''The parts our project is made up of:'''
| + | |
| - | * [[Team:NYMU-Taipei/Project/pH Sensor | pH Sensor]]
| + | |
| - | ** A sensor of '''proton concentration (pH)'''
| + | |
| - | * [[Team:NYMU-Taipei/Project/Attachment | Attachment]]
| + | |
| - | ** An '''Attachment anchor''' that attaches to the small intestine
| + | |
| - | * [[Team:NYMU-Taipei/Project/Urea | Clearance of Urea]]
| + | |
| - | ** A '''Urea''' clearance device
| + | |
| - | * [[Team:NYMU-Taipei/Project/Phosphate | Clearance of Phosphate]]
| + | |
| - | ** A '''Phosphate''' clearance and balance device
| + | |
| - | * [[Team:NYMU-Taipei/Project/Guanidine | Clearance of Guanidine]]
| + | |
| - | ** A '''Guanidine''' clearance device
| + | |
| - | * [[Team:NYMU-Taipei/Project/Time Regulation | Time Regulation]]
| + | |
| - | ** Enables detachment from the small intestine after a certain amount of time
| + | |
| - | ** Experimenting with two systems:
| + | |
| - | *** [[Team:NYMU-Taipei/Project/Time_Regulation/Cyanoxilator|Cyanoxilator]]: A tuneable cyanobacterial natural (sinusoidal) oscillator implemented in ''E. coli''.
| + | |
| - | *** [[Team:NYMU-Taipei/Project/Time_Regulation/Reloxilator|Reloxilator]]: A tuneable intracell-synchronized relaxation oscillator.
| + | |
| - | | + | |
| - | | style="vertical-align:top;" | {{:Team:NYMU-Taipei/News}} <!-- Edit the News page for news please. -->
| + | |
| - | |}
| + | |
| - | {{:Team:NYMU-Taipei/Footer}}
| + | |
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