"
Team:NYMU-Taipei
From 2011.igem.org
| Line 26: | Line 26: | ||
{{:Team:NYMU-Taipei/Our institute}} | {{:Team:NYMU-Taipei/Our institute}} | ||
|} | |} | ||
| - | |||
| - | |||
| - | |||
Revision as of 03:29, 6 October 2011
|
Tailoring Your Avatar
Create wireless neuro-stimulator, focusing on achieving remote neuro-stimulation to minimize the invasion and damage to the neuron
Optogenetics, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved.
|
To achieve this goal, we use a species of magnetic bacteria, Magnetospirillum magneticum AMB-1. We have chosen mms13, a transmembrane protein as our target for protein design in this bacterium, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we choose three genes to achieve symbiosis within glial cell: MinC, a division inhibitor, INV, a gene for invasion and LLO, a gene for facilitated escape from phagosomes.
|
