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| - | <font size="5"><strong> Project 1(the web project):</strong></font><p> | + | <font size="5"><strong> the super E.coli Architect project(the software project):</strong></font><p> |
| - | China's wine culture has developed for thousands of years,and the wine as a traditional drink is closely | + | |
| - | linked with people's life. But excessive drinking will bring a lot of inconvenience, causing many social
| + | <hr size="5" color="#C2E69F"> |
| - | problems. For example, in recent years, drunk driving has become a ferocioustraffic killer.Therefore,we hope to
| + | <font size="5"><strong> team show(the software project):</strong></font><p> |
| - | develop a kind of engineering bacteria, which can reproduct in the human body , and has the ability of
| + | Super |
| - | decomposition of excess alcohol function.<br>
| + | |
| - | As the host bacteria of exogenous gene expression,lactobacillus' superiority is mainly manifested in the
| + | |
| - | following:1.lactobacillus can colonize in the respiratory system, digestive system and urinary system, playing
| + | |
| - | an important role in maintain ecological balance; 2.lactobacillus has confirmed that has no pathogenicity in
| + | |
| - | food industry's various fields of long-term application, is recognized as the security level (GRAS, generally
| + | |
| - | recognized as safe) microorganisms.As a result , we choose the lactic acid bacteria as recipients in gene
| + | |
| - | engineering.<br>
| + | |
| - | In the human body 's metabolism process, the alcohol is mainly catalyzed into acetaldehyde acetaldehyde by
| + | |
| - | alcohol dehydrogenase ( ADH) in liver, further by acetaldehyde dehydrogenase (ALDH ) catalytic transformation
| + | |
| - | into acetic acid.We found two genes expressing of ADH and ALDH, ADH1B2 and ALDH2, hoping to put them into
| + | |
| - | BioBrick, introducing into Lactobacillus expression. At the same time we will introduce promoter of lactate
| + | |
| - | detection as well as self-cracking mechanism, improving the gene pathway.<p>
| + | |
| - | <hr size="5" color="#C2E69F">
| + | |
| - | <font size="5"><strong> Project 2(the software project):</strong></font><p> | + | |
| - | Super E.coli Architect is a design software of engineering bacteria. It offers a convenient and efficient
| + | |
| - | design platform,which contributes to making simple ideas into a complete solutions. The existing synthetic biology softwares
| + | |
| - | involve some specific functions such as finding genes and metabolism pathways, modeling and biobrick design.And these softwares
| + | |
| - | are often oriented to scientific researchers. But we think that thereis a hope in synthetic biology to turn the science of artificial
| + | |
| - | biosystem into a engineering program having a standard process. Therefore, we constructed a software, Super E.coli Architect,
| + | |
| - | oriented to designers more than scientists.Providing all the necessary technical support,SuperE.coli Architect can release
| + | |
| - | desighners from technical details,helping them work as the architects,allowing them to take more attention into constructing
| + | |
| - | kinds engineering bacterias for solving practical problems.<br>
| + | |
| - | | + | |
| - | | + | |
| | </div> | | </div> |
| | </div> | | </div> |
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