Team:UT Dallas

From 2011.igem.org

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<h2>Immunobots: a step towards intelligent probiotics</h2>
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The human bowel hosts a rich diversity of symbiotic microflora that provides a powerful
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engineering platform for intelligent probiotics. These immunobots will ideally work in-sync
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and enhance natural self-repair mechanisms for a range of intestinal diseases associated with
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tissue damage. Towards this end, we engineered a bacterial chemotaxis pathway that utilizes a
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chimeric receptor to successfully interface with the immune system. In addition, we introduced
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an inducible secondary bacterial population that can trigger system-wide self-destruction,
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conferring an additional level of user control. Each module of our system was characterized
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using fluorescent reporters and the integrated parts were evaluated by controlled experiments
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involving wound signal gradients. We envision a probiotic solution that can facilitate localized
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tissue repair for damage resulting from inflammatory bowel diseases, including ulcerative colitis
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and Crohn’s disease.</td>
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Revision as of 21:49, 28 September 2011