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Team:MIT
From 2011.igem.org
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| - | MIT's iGEM project focuses on genetically programming tissue self-construction to achieve specific spatiotemporal patterns of cell differentiation (initially with fluorescence, ultimately with cell fate regulators). This is accomplished through synthetic gene networks that integrate control over engineered cell-cell communication pathways, intracellular information processing circuits, and cell-cell adhesion. Through engineered control of these mechanisms, we are investigating how programmed local rules of interactions between cells can lead to the emergence of desired global spatiotemporal properties. <p><p> | + | MIT's iGEM project focuses on genetically programming tissue self-construction to achieve specific spatiotemporal patterns of cell differentiation (initially with fluorescence, ultimately with cell fate regulators). This is accomplished through synthetic gene networks that integrate control over engineered cell-cell communication pathways, intracellular information processing circuits, and cell-cell adhesion. Through engineered control of these mechanisms, we are investigating how programmed local rules of interactions between cells can lead to the emergence of desired global spatiotemporal properties. <p> |
| + | <p>Below is an animation created by our team member Jenny Cheng, showing the Notch-Delta interaction leading to the cleavage of the Notch intracellular domain, which enters the nucleus and leads to the expression of cadherins, which cause cells to bind to other cells expressing the same cadherin. | ||
<iframe width="420" height="300" src="http://www.youtube.com/embed/-3NgxSHqT10" frameborder="0" allowfullscreen></iframe> | <iframe width="420" height="300" src="http://www.youtube.com/embed/-3NgxSHqT10" frameborder="0" allowfullscreen></iframe> | ||
Revision as of 18:19, 27 September 2011
Project
MIT's iGEM project focuses on genetically programming tissue self-construction to achieve specific spatiotemporal patterns of cell differentiation (initially with fluorescence, ultimately with cell fate regulators). This is accomplished through synthetic gene networks that integrate control over engineered cell-cell communication pathways, intracellular information processing circuits, and cell-cell adhesion. Through engineered control of these mechanisms, we are investigating how programmed local rules of interactions between cells can lead to the emergence of desired global spatiotemporal properties.
Below is an animation created by our team member Jenny Cheng, showing the Notch-Delta interaction leading to the cleavage of the Notch intracellular domain, which enters the nucleus and leads to the expression of cadherins, which cause cells to bind to other cells expressing the same cadherin.
