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Team:UPO-Sevilla/Project/Improving Flip Flop/Bioinformatics/Docking SspB-ClpX
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<h1>Docking SspB-ClpX</h1> | <h1>Docking SspB-ClpX</h1> | ||
| - | + | <h2>Goal</h2> | |
| + | <p>To generate an interaction model for the SspB-ClpX system used in our V sublab.</p> | ||
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| + | <h2>Background</h2> | ||
| + | <p>In the ClpXP proteolysis model reported by McGinness et al (McGinnes et al, 2006 - FALTA LINK) SspB acts as an adaptor protein which helps in the target protein degradation (general information of SspB is presented in table 1). This SspB protein interacts with the protease subunit ClpX. ClpX (information of this protein available in table 2) forms a protease complex with ClpP in which the target protein is degraded. </p> | ||
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| + | <div class="center"> | ||
| + | <img width="700px" src="https://static.igem.org/mediawiki/2011/6/69/UPOSevilla-BioInfo-Fig11.jpg" alt="glmS gene multialignment of several organisms in which the Tn7 family transposon has been found" /> </div> | ||
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| + | <p><strong>Table 1</strong>. Relevant information of SspB protein from Uniprot protein database entry B1XHK1 (http://www.uniprot.org/uniprot/B1XHK1) and the corresponding SspB Pfam database entry. (http://pfam.sanger.ac.uk/protein/B1XHK1)</p> | ||
</div> | </div> | ||
Revision as of 18:40, 19 September 2011
Docking SspB-ClpX
Goal
To generate an interaction model for the SspB-ClpX system used in our V sublab.
Background
In the ClpXP proteolysis model reported by McGinness et al (McGinnes et al, 2006 - FALTA LINK) SspB acts as an adaptor protein which helps in the target protein degradation (general information of SspB is presented in table 1). This SspB protein interacts with the protease subunit ClpX. ClpX (information of this protein available in table 2) forms a protease complex with ClpP in which the target protein is degraded.
Table 1. Relevant information of SspB protein from Uniprot protein database entry B1XHK1 (http://www.uniprot.org/uniprot/B1XHK1) and the corresponding SspB Pfam database entry. (http://pfam.sanger.ac.uk/protein/B1XHK1)
Sponsors
