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- | <!--<!DOCTYPE html PUBLIC "-//W3C//DTD XHTML 1.0 Transitional//EN" "http://www.w3.org/TR/xhtml1/DTD/xhtml1-transitional.dtd">--> | + | __NOTOC__ |
- | <html xmlns="http://www.w3.org/1999/xhtml"> | + | <html> |
- | <head>
| + | <!-- Internet Explorer PNG fix - START /--> |
- | <title>biz solution</title>
| + | <!--[if lt IE 7]> |
- | <meta http-equiv="Content-Type" content="text/html; charset=utf-8" />
| + | <script src="http://ie7-js.googlecode.com/svn/version/2.1(beta4)/IE8.js">IE7_PNG_SUFFIX=".png";</script> |
- | <link href="style.css" rel="stylesheet" type="text/css" />
| + | <![endif]--> |
- | <script type="text/javascript" src="js/jquery-1.3.2.min.js"></script> | + | <!-- Internet Explorer PNG fix - END /--> |
- | <script type="text/javascript" src="js/script.js"></script>
| + | |
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| + | |
- | <script type="text/javascript" src="js/cuf_run.js"></script> | + | |
| | | |
- | </head> | + | <script type="text/javascript" src="http://ajax.googleapis.com/ajax/libs/jqueryui/1.8.2/jquery-ui.min.js"></script> |
- | <body> | + | <script type='text/javascript' src='https://2011.igem.org/Team:UT_Dallas/jquery.lavalamp-1.3.4b.js?action=raw&ctype=text/javascript'></script> |
- | <style media="screen" type="text/css"> | + | |
- | @charset "utf-8";
| + | <script type="text/javascript"> |
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| + | height:auto !important; |
- | margin:0 auto;
| + | height:100%; |
- | width:970px; | + | min-height:100%; |
| } | | } |
- | .logo {
| + | #bodyContent { border: none; padding:0; margin:0; width:100%; |
- | float:left;
| + | height:auto !important; |
- | width:300px;
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- | width:317px;
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- | text-align:center;
| + | |
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| + | |
- | .menu_nav {
| + | |
- | margin:0;
| + | |
- | padding:0;
| + | |
- | height:81px; | + | |
- | }
| + | |
- | .menu_nav ul {
| + | |
- | list-style:none; | + | |
- | margin:0;
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| + | |
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| + | |
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- | display:block;
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- | margin:0 5px 0 0;
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- | padding:10px 15px;
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- | text-decoration:none;
| + | |
- | font-size:13px;
| + | |
- | line-height:16px;
| + | |
- | background:#cccccc;
| + | |
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| + | |
- | .menu_nav ul li.active a, .menu_nav ul li a:hover {
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- | text-decoration:none;
| + | |
- | background:#78bbe6;
| + | |
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| + | |
- | .content {
| + | |
- | padding:13px;
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- | margin:0;
| + | |
- | }
| + | |
- | .mainbar {
| + | |
- | margin:0;
| + | |
- | padding:0;
| + | |
- | float:right;
| + | |
- | width:643px;
| + | |
- | }
| + | |
- | .mainbar img {
| + | |
- | padding:4px;
| + | |
- | border:1px solid #f2f2f1;
| + | |
- | background:#FFF;
| + | |
- | }
| + | |
- | .mainbar img.fl {
| + | |
- | margin:4px 16px 4px 0;
| + | |
- | float:left;
| + | |
- | }
| + | |
- | .mainbar .article {
| + | |
- | margin:0;
| + | |
- | padding:10px 0 5px 20px;
| + | |
- | }
| + | |
- | .mainbar .article a {
| + | |
- | color:#78bbe6;
| + | |
- | }
| + | |
- | .mainbar .post-data a {
| + | |
- | color:#595959;
| + | |
- | }
| + | |
- | .mainbar .spec a.rm, .mainbar a.com {
| + | |
- | color:#FFF;
| + | |
- | }
| + | |
- | .sidebar {
| + | |
- | padding:0;
| + | |
- | float:left;
| + | |
- | width:301px;
| + | |
- | }
| + | |
- | .sidebar .gadget {
| + | |
- | margin:0;
| + | |
- | padding:10px 20px 5px 0;
| + | |
- | }
| + | |
- | .sidebar .gadget .title {
| + | |
- | text-align:right;
| + | |
- | }
| + | |
- | .sidebar .gadget span.q {
| + | |
- | text-align:right;
| + | |
- | font:normal 60px/12px Arial, Helvetica, sans-serif;
| + | |
- | color:#d9d9d9;
| + | |
- | }
| + | |
- | ul.sb_menu, ul.ex_menu, .testi {
| + | |
- | margin:0;
| + | |
- | padding:0;
| + | |
- | color:#939393;
| + | |
- | list-style:none;
| + | |
- | }
| + | |
- | ul.sb_menu li, ul.ex_menu li {
| + | |
- | margin:0;
| + | |
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| + | |
- | ul.sb_menu li {
| + | |
- | padding:2px 0;
| + | |
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| + | |
- | ul.ex_menu li {
| + | |
- | padding:2px 0;
| + | |
- | }
| + | |
- | ul.sb_menu li a, ul.ex_menu li a {
| + | |
- | display:block;
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- | color:#959595;
| + | |
- | text-decoration:none;
| + | |
- | padding:5px 5px 5px 15px;
| + | |
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- | https://static.igem.org/mediawiki/2011/archive/e/e1/20110714195925%21Menu_link.gif) no-repeat left center;
| + | |
- | }
| + | |
- | ul.ex_menu li span {
| + | |
- | padding:0 0 0 15px; | + | |
- | }
| + | |
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| + | |
- | .content .mainbar .comment {
| + | |
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| + | |
- | padding:16px 0 0 0;
| + | |
- | }
| + | |
- | .content .mainbar .comment img.userpic {
| + | |
- | border:1px solid #dedede;
| + | |
- | margin:10px 16px 0 0;
| + | |
- | padding:0;
| + | |
- | float:left;
| + | |
- | }
| + | |
- | .fbg {
| + | |
- | margin:0;
| + | |
- | padding:20px;
| + | |
- | background:#78bbe6;
| + | |
- | }
| + | |
- | .fbg img {
| + | |
- | padding:4px;
| + | |
- | border:1px solid #cfd2d4;
| + | |
- | background-color:#fff;
| + | |
- | }
| + | |
- | .fbg p, .fbg h2 {
| + | |
- | color:#fbfbfb;
| + | |
- | }
| + | |
- | .fbg a {
| + | |
- | color:#fbfbfb;
| + | |
- | }
| + | |
- | .fbg .col {
| + | |
- | margin:0;
| + | |
- | float:left;
| + | |
- | background:url(
| + | |
- | https://static.igem.org/mediawiki/2011/0/04/Fbg_line.gif) repeat-y right;
| + | |
- | }
| + | |
- | .fbg .c1 {
| + | |
- | padding:0 20px 0 0;
| + | |
- | width:260px;
| + | |
- | }
| + | |
- | .fbg .c2 {
| + | |
- | padding:0 20px;
| + | |
- | width:320px;
| + | |
- | }
| + | |
- | .fbg .c3 {
| + | |
- | padding:0 0 0 20px;
| + | |
- | width:270px;
| + | |
- | background:none;
| + | |
- | }
| + | |
- | .fbg .c1 img {
| + | |
- | margin:8px 16px 8px 0;
| + | |
- | }
| + | |
- | .fbg .c3 img {
| + | |
- | margin:8px 16px 4px 0;
| + | |
- | float:left;
| + | |
- | }
| + | |
- | .footer {
| + | |
- | }
| + | |
- | .footer_resize {
| + | |
- | margin:0 auto;
| + | |
- | padding:20px;
| + | |
- | width:930px;
| + | |
- | }
| + | |
- | .footer p {
| + | |
- | margin:0;
| + | |
- | padding:4px 0;
| + | |
- | }
| + | |
- | .footer a {
| + | |
- | color:#9a9a9a;
| + | |
- | padding:inherit;
| + | |
- | text-decoration:underline;
| + | |
- | }
| + | |
- | .footer a:hover {
| + | |
- | text-decoration:none;
| + | |
- | }
| + | |
- | .footer .lf {
| + | |
- | float:left;
| + | |
- | }
| + | |
- | .footer .rf {
| + | |
- | float:right;
| + | |
- | }
| + | |
- | ol {
| + | |
- | list-style:none;
| + | |
- | }
| + | |
- | ol li {
| + | |
- | display:block;
| + | |
- | clear:both;
| + | |
- | }
| + | |
- | ol li label {
| + | |
- | display:block;
| + | |
- | margin:0;
| + | |
- | padding:16px 0 0 0;
| + | |
- | }
| + | |
- | ol li input.text {
| + | |
- | width:480px;
| + | |
- | border:1px solid #c0c0c0;
| + | |
- | margin:2px 0;
| + | |
- | padding:5px 2px;
| + | |
- | height:16px;
| + | |
- | background:#fff;
| + | |
- | }
| + | |
- | ol li textarea {
| + | |
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| + | |
- | border:1px solid #c0c0c0;
| + | |
- | margin:2px 0;
| + | |
- | padding:2px;
| + | |
- | background:#fff;
| + | |
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| + | |
- | ol li .send {
| + | |
- | margin:16px 0 0 0;
| + | |
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| + | |
- | .search {
| + | |
- | padding:0;
| + | |
- | margin:0;
| + | |
- | }
| + | |
- | .search span {
| + | |
- | width:280px;
| + | |
- | display:block;
| + | |
- | background:#FFF;
| + | |
- | height:29px;
| + | |
- | margin:0;
| + | |
- | padding:0;
| + | |
- | border:1px solid #e1dddd;
| + | |
- | }
| + | |
- | .search input#s {
| + | |
- | float:left;
| + | |
- | width:230px;
| + | |
- | padding:7px 0 7px 10px;
| + | |
- | margin:0;
| + | |
- | border:0;
| + | |
- | background:none;
| + | |
- | color:#afaeae;
| + | |
- | font:normal 12px/15px Arial, Helvetica, sans-serif;
| + | |
- | }
| + | |
- | .search .btn {
| + | |
- | float:left;
| + | |
- | padding:0;
| + | |
- | margin:0;
| + | |
- | border:0;
| + | |
- | width:auto;
| + | |
- | }
| + | |
- | .pagenavi {
| + | |
- | clear:both;
| + | |
- | font:normal 11px Arial, Helvetica, sans-serif;
| + | |
- | margin:0 auto;
| + | |
- | text-align:right;
| + | |
- | padding:20px 0 20px 20px;
| + | |
- | }
| + | |
- | .pagenavi a, .pagenavi .current {
| + | |
- | margin-left:3px;
| + | |
- | padding:3px 8px;
| + | |
- | text-decoration:none;
| + | |
- | color:#939393;
| + | |
- | background:#f9fbfc;
| + | |
- | border:1px solid #d9e3cb;
| + | |
- | }
| + | |
- | .pagenavi a:hover, .pagenavi .current {
| + | |
- | background:#78bbe6;
| + | |
- | color:#FFF;
| + | |
- | }
| + | |
- | .pagenavi .pages {
| + | |
- | float:left;
| + | |
- | }
| + | |
- | .fl {
| + | |
- | float:left;
| + | |
- | }
| + | |
- | .fr {
| + | |
- | float:right;
| + | |
- | }
| + | |
- | .clr {
| + | |
- | clear:both;
| + | |
- | padding:0;
| + | |
- | margin:0;
| + | |
- | width:100%;
| + | |
- | font-size:0;
| + | |
- | line-height:0;
| + | |
| } | | } |
| + | #top-section { z-index: 2; height: 15px; margin: 0px; margin-left: auto; margin-right: auto; margin-bottom: 0 !important; padding:0; border: none; font-size: 10px;} |
| + | #p-logo { height:1px; overflow:hidden; display: none;} |
| + | #search-controls { overflow:hidden; display:block; background: none; position: absolute; top: 100px; right: 40px;} |
| + | .left-menu { width: 500px !important; display:block; margin-top:-80px; border: none; text-align: right;} |
| + | .left-menu ul { border: none; } |
| + | #menubar.right-menu { width:300px; display:block; float:left; margin-top:-80px; border: none;} |
| + | .right-menu ul { border: none; width: 300px;} |
| + | #footer-box { background: none repeat scroll 0 0 transparent;border: medium none;} |
| + | .visualClear { display: none; } |
| + | #footer { border: none; width: 850px; margin: 0 auto; padding: 0;} |
| + | .firstHeading { display: none;} |
| + | #f-list a { color: #333; font-size: 10px;} |
| + | #f-list a:hover { color: #666;} |
| + | .printfooter { display: none; } |
| + | #footer ul { margin: 0; padding: 0;} |
| + | #footer ul li { margin-top: 0; margin-bottom: 0; margin-left: 10px; margin-right: 10px; padding: 0;} |
| + | #search-controls { display:none; } |
| + | h3#siteSub { display: none;} |
| + | #contentSub {display: none;} |
| + | #catlinks {display: none;} |
| + | |
| + | h1{border:none; width: 100%; clear: both;} |
| </style> | | </style> |
- | <div class="main"> | + | <div class="container"> |
- | <a href = "https://igem.org/Team_Wikis?year=2011"><img src="https://static.igem.org/mediawiki/2011/a/af/Page_Link.png" ALIGN = "right" /></a>
| + | <div id="header"> |
- | <div class="header">
| + | </html>{{:Team:UT_Dallas/Template:links}}<html> |
- | <div class="logo">
| + | |
- | <h1><span>UTDallas</span> iGem<small></small></a></h1>
| + | |
| | | |
- | </div>
| + | </div> |
- |
| + | |
- | <div class="menu_nav">
| + | |
| | | |
- | <ul>
| + | <div class="contents"> |
- | <li class = "active"><a href="#"><font size="3" face="verdana">Home</a></font></li>
| + | <div id="container2"> |
- | <li><a href="https://2011.igem.org/Team:UT_Dallas/Team"><font size="3" face="verdana">Team</a></font></li>
| + | <div id="container1"> |
- | <li><a href="https://2011.igem.org/Team:UT_Dallas/Project"><font size="3" face="verdana">Project</a></font></li>
| + | <div id="left"> |
- | <li><a href="https://2011.igem.org/Team:UT_Dallas/Protocols"><font size="3" face="verdana">Protocols</a></font></li>
| + | </html>{{:Team:UT_Dallas/Template:menu}}<html> |
- | <li><a href="https://2011.igem.org/Team:UT_Dallas/Parts"><font size="3" face="verdana">Parts</a></font></li>
| + | </div> |
- | <li><a href="https://2011.igem.org/Team:UT_Dallas/Modeling"><font size="3" face="verdana">Modeling</a></font></li>
| + | <div id="right"> |
- | <li><a href="https://2011.igem.org/Team:UT_Dallas/Notebook"><font size="3" face="verdana">Notebook</a></font></li>
| + | <h2>Immunobots: a step towards intelligent probiotics</h2> |
- | <li><a href="https://2011.igem.org/Team:UT_Dallas/HumanPractices"><font size="3" face="verdana">Human Practices</a></font></li>
| + | <br> |
- | <li><a href="https://2011.igem.org/Team:UT_Dallas/Gallery"><font size="3" face="verdana">Gallery</a></font></li>
| + | <table width="720"> |
- |
| + | <tr><td valign="top" > |
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| + | The human bowel hosts a rich diversity of symbiotic microflora that provides a powerful |
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| + | engineering platform for intelligent probiotics. These immunobots will ideally work in-sync |
- | </div>
| + | and enhance natural self-repair mechanisms for a range of intestinal diseases associated with |
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| + | tissue damage.<br><br>Towards this end, we engineered a bacterial chemotaxis pathway that utilizes a |
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| + | chimeric receptor to successfully interface with the immune system (<b>immunobot</b>). In addition, we introduced |
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| + | an inducible secondary bacterial population that can trigger system-wide self-destruction, |
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| + | conferring an additional level of user control (<b>killbot</b>). Each module of our system was characterized |
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| + | using fluorescent reporters and the integrated parts were evaluated by controlled experiments |
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| + | involving wound signal gradients.<br><br>We envision a probiotic solution that can facilitate localized |
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| + | tissue repair for damage resulting from inflammatory bowel diseases, including ulcerative colitis |
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| + | and Crohn’s disease.</td> |
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| + | <td valign="top"> |
- | <h2><span><b> Immunobots: a step towards intelligent probiotics</b></span></h2>
| + | <img src="https://static.igem.org/mediawiki/2011/2/2b/IGEM2011.jpg" width="200" style="margin-left: 26px; border: 1px solid #8E8E8E"> |
- | <p> Abstract</p>
| + | </td> |
- | <p>The human bowel hosts a rich diversity of symbiotic microflora that provides a powerful engineering platform for intelligent probiotics. These “immunobots” will ideally work in-sync and enhance natural self-repair mechanisms for a range of intestinal diseases associated with tissue damage. Towards this end, we engineered a bacterial chemotaxis pathway that utilizes a chimeric receptor to successfully interface with the immune system. In addition, we introduced an inducible secondary bacterial population that can trigger system-wide self-destruction, conferring an additional level of user control. Each module of our system was characterized using fluorescent reporters and the integrated parts were evaluated by controlled experiments involving wound signal gradients. We envision a probiotic solution that can facilitate localized tissue repair for damage resulting from inflammatory bowel diseases, including ulcerative colitis and Crohn’s disease.</p>
| + | </tr> |
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