Team:UT Dallas

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      <h1><span>UTDallas</span> iGem<small></small></a></h1>
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        <li class = "active"><a href="#"><font size="3" face="verdana">Home</a></font></li>
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        <li><a href="https://2011.igem.org/Team:UT_Dallas/Team"><font size="3" face="verdana">Team</a></font></li>
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        <li><a href="https://2011.igem.org/Team:UT_Dallas/Protocols"><font size="3" face="verdana">Protocols</a></font></li>
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        <li><a href="https://2011.igem.org/Team:UT_Dallas/Parts"><font size="3" face="verdana">Parts</a></font></li>
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        <li><a href="https://2011.igem.org/Team:UT_Dallas/Modeling"><font size="3" face="verdana">Modeling</a></font></li>
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        <li><a href="https://2011.igem.org/Team:UT_Dallas/Notebook"><font size="3" face="verdana">Notebook</a></font></li>
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<h2>Immunobots: a step towards intelligent probiotics</h2>
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        <li><a href="https://2011.igem.org/Team:UT_Dallas/HumanPractices"><font size="3" face="verdana">Human Practices</a></font></li>
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<table width="720">
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<tr><td valign="top" >
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      </ul>
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The human bowel hosts a rich diversity of symbiotic microflora that provides a powerful
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      <div class="clr"></div>
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engineering platform for intelligent probiotics. These immunobots will ideally work in-sync
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    </div>
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and enhance natural self-repair mechanisms for a range of intestinal diseases associated with
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tissue damage.<br><br>Towards this end, we engineered a bacterial chemotaxis pathway that utilizes a
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    <div class="hbg"><img src="https://static.igem.org/mediawiki/2011/b/b2/Original_Banner_for_UTD_website.png" width="970" height="300" alt="" />
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chimeric receptor to successfully interface with the immune system (<b>immunobot</b>). In addition, we introduced
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an inducible secondary bacterial population that can trigger system-wide self-destruction,
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conferring an additional level of user control (<b>killbot</b>). Each module of our system was characterized
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using fluorescent reporters and the integrated parts were evaluated by controlled experiments
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involving wound signal gradients.<br><br>We envision a probiotic solution that can facilitate localized
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tissue repair for damage resulting from inflammatory bowel diseases, including ulcerative colitis
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and Crohn’s disease.</td>
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<td valign="top">
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          <h2><span><b> UTDallas iGem 2011</b></span></h2>
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          <p>Tissue damage characterizes a range of medical conditions that can be particularly difficult to manage without restrictively risky or expensive intervention. The human body hosts a rich diversity of symbiotic microflora that provides a powerful engineering platform for synthetic bacterial systems. We aim to construct a probiotic solution that successfully interfaces with the immune system to facilitate localized tissue repair.</p>
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