Team:UT Dallas

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</html>{{:Team:UT_Dallas/Template:links}}<html>
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      <h1><span>UTDallas</span> iGem<small></small></a></h1>
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        <li class = "active"><a href="https://2011.igem.org/Team:UT_Dallas"><font size="3" face="verdana">Home</a></font></li>
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          <h2><span><b> UTDallas iGem 2011: Project Description</b></span></h2>
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          <p>Tissue damage characterizes a range of medical conditions that can be particularly difficult to manage without restrictively risky or expensive intervention. The human body hosts a rich diversity of symbiotic microflora that provides a powerful engineering platform for synthetic bacterial systems. We aim to construct a probiotic solution that successfully interfaces with the immune system to facilitate localized tissue repair.</p>
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<p class="spec"><a href="https://2011.igem.org/wiki/index.php?title=Team:UT_Dallas/Project" class="rm fl"><font size="4" face="verdana">Read more</a></font></p>
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<h2>Immunobots: a step towards intelligent probiotics</h2>
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<br>
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<table width="720">
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<tr><td valign="top" >
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The human bowel hosts a rich diversity of symbiotic microflora that provides a powerful
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engineering platform for intelligent probiotics. These immunobots will ideally work in-sync
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and enhance natural self-repair mechanisms for a range of intestinal diseases associated with
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tissue damage.<br><br>Towards this end, we engineered a bacterial chemotaxis pathway that utilizes a
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chimeric receptor to successfully interface with the immune system (<b>immunobot</b>). In addition, we introduced
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an inducible secondary bacterial population that can trigger system-wide self-destruction,
 +
conferring an additional level of user control (<b>killbot</b>). Each module of our system was characterized
 +
using fluorescent reporters and the integrated parts were evaluated by controlled experiments
 +
involving wound signal gradients.<br><br>We envision a probiotic solution that can facilitate localized
 +
tissue repair for damage resulting from inflammatory bowel diseases, including ulcerative colitis
 +
and Crohn’s disease.</td>
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<td valign="top">
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