Team:NYMU-Taipei

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Goal

Create wireless neuro-stimulator, focusing on achieving remote neuro-stimulation to minimize invasion and damage to the neuron.

Why Do We Want to Do That?

Optogenetics, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved.

Specific Aims

(1) Wireless stimulation for neurons

(2) Minimization of neuro-immuno response

Our Design

To achieve this goal, we use a species of magnetic bacterium, Magnetospirillum magneticum AMB-1. We have chosen mms13, a transmembrane protein as our target for protein design in this bacterium, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we have utilized three genes to achieve neurosymbiosis within glial cells: MinC, a division inhibitor, INV, a gene for invasion and LLO, a gene for facilitating escapes from phagosomes.

Our design is made up of the following two devices:

(1) Optomagnetic Design

Bridging magnetics and optogenetics.

(2) NeuroSymbiosis

Enabling magnetotactic bacteria to be neurosymbiosis with glia cells.

3D Deep Brain Stimulation model

Summary of Our Achievements

Our Institute

(1) The official web sites of our school - National Yang Ming University (NYMU):

[http://web.ym.edu.tw/front/bin/home.phtml in Chinese]

[http://nymu-e.web.ym.edu.tw/front/bin/home.phtml in English]

(2) Follow the two links below to see The Beauty of NYMU

[http://issue.ym.edu.tw/cia/new/ Take a panoramic scenery view of our university]

[http://issue.ym.edu.tw/cia/new/tw/ym720.html Take a tour of our university]

Retrieved from "http://2011.igem.org/Team:NYMU-Taipei"

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+=<font size=5><font color=crimson>'''Tailoring Your Avatar'''</font></font>=
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+=='''<font size=4><font color=green>Goal</font></font>'''==
-|}
+<font size=3>Create <b>wireless neuro-stimulator</b>, focusing on achieving remote neuro-stimulation to minimize invasion and damage to the neuron.</font>
-<html>
+=='''<font size=4><font color=green>Why Do We Want to Do That?</font></font>==
-<div id="box" style="width: 700px; margin-left: 137px; padding: 5px; border: 3px solid #000; background-color: #fe2b33;">
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+<font size=3><b>Optogenetics</b>, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved. </font>
-{|align="justify"
-|iD'Avatar
-|[[Image:NYMU-Taipei_logo.png|200px|right|frame]]
-|-
-|
-iD'Avatar, a safer bio-medical interface created by NYMU-Taipei team. In this year, we aim for developing a safer medical environment of optogenetics therapy. Optogenetics is the latest neuroscientific method breakthrough promised to take over electrode stimulation due to improved specificity for certain types of neurons, reversible bi-directional stimulation, and elevated spatial precision. However, to achieve neuronal network stimulation, light cables are still needed, which only substitutes the original steel electrodes, leaving long-standing annoying issues regarding immune responses unresolved. By the way, many countries haven’t established their own electronic medical records; thus, communication between doctors and doctors is really a tough problem. Furthermore, when you travel around the world, you may encounter the same problem that without a medical record, doctors may do a wrong decision which may cause exacerbations or even death. Two systems have been designed to solve the problems above: wireless neuro-stimulator and MRY labeling system.
-(1) Wireless neuro-stimulator - focuses on achieving remote neuro-stimulation to minimize the invasion and damage to the brain tissue by using a species of magnetic bacteria, Magnetospirillum magneticum AMB-1. On the magnetosome membrane of AMB-1 locates a transmembrane protein, Mms13, which binds very tightly to the magnetite. And we have chosen it as our target for protein design as it serves as a linker between reception of magnetic field and signal transduction directly within biological systems. Furthermore, the aim to achieve intracerebral symbiosis is also highly stressed. (2) MRY labeling system- An efficient way to prevent medical negligence. MRY stands for Medical Record Yeast, which contains your medical records in a DNA encoded fashion, which can’t be easily decrypted. This design can prove your own privacy and information safety. Medical records yeasts which can be symbiotic with human skin are labeled on your upper arm. Doctors will do a quick screen to collect Medical records yeasts and use special DNA hybridization chip to decrypt the medical records and do the diagnosis properly. this system can help the medical records exchange between doctors and doctors, preventing information asymmetry happens in some countries without proper electronic medical records system or when having an emergency call in foreign hospitals.''
-|[[Image:NYMU-Taipei_team.png|right|frame|Your team picture]]
-|-
-|
-|align="center"|[[Team:NYMU-Taipei | Team Example]]
-|}
-<!--- The Mission, Experiments --->
+=='''<font size=4><font color=green>Specific Aims</font></font>'''==
+<font size=4><font color=mediumblue>'''(1) Wireless stimulation for neurons'''</font></font>
+<font size=4><font color=mediumblue>'''(2) Minimization of neuro-immuno response'''</font></font>
+<center><html>
+<iframe width="450" height="349" src="http://www.youtube.com/embed/uB66Q4JP6P0?hl=zh&fs=1" frameborder="0" allowfullscreen></iframe>
+</html></center>
+=='''<font size=4 color=green>Our Design</font>'''==
+<font size=3>
+To achieve this goal, we use a species of magnetic bacterium,'' Magnetospirillum magneticum'' AMB-1. We have chosen <b>mms13</b>, a transmembrane protein as our target for protein design in this bacterium, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we have utilized three genes to achieve <b>neurosymbiosis</b> within glial cells: <b>''MinC''</b>, a division inhibitor, <b>''INV''</b>, a gene for invasion and <b>''LLO''</b>, a gene for facilitating escapes from phagosomes.</font>
-{| style="color:#1b2c8a;background-color:#0c6;" cellpadding="3" cellspacing="1" border="1" bordercolor="#fff" width="62%" align="center"
+'''<font size=3>Our design is made up of the following two devices:</font>'''
-!align="center"|[[Team:NYMU-Taipei|Home]]
-!align="center"|[[Team:NYMU-Taipei/Team|Team]]
+[https://2011.igem.org/Team:NYMU-Taipei/optomagnetic-design <font size=4><font color=mediumblue>'''(1) <u>Optomagnetic Design</u>'''</font></font>]
-!align="center"|[https://igem.org/Team.cgi?year=2011&team_name=NYMU-Taipei Official Team Profile]
-!align="center"|[[Team:NYMU-Taipei/Project|Project]]
+<font size=3>Bridging magnetics and optogenetics.</font>
-!align="center"|[[Team:NYMU-Taipei/Parts|Parts Submitted to the Registry]]
-!align="center"|[[Team:NYMU-Taipei/Modeling|Modeling]]
+[https://2011.igem.org/Team:NYMU-Taipei/immunological-solution <font size=4><font color=mediumblue>'''(2)<u> NeuroSymbiosis</u>'''</font></font>]
-!align="center"|[[Team:NYMU-Taipei/Notebook|Notebook]]
-!align="center"|[[Team:NYMU-Taipei/Safety|Safety]]
+<font size=3>Enabling magnetotactic bacteria to be neurosymbiosis with glia cells.</font>
-!align="center"|[[Team:NYMU-Taipei/Attributions|Attributions]]
+=='''<font size=4><font color=green>3D Deep Brain Stimulation model</font></font>'''==
-|}
+<center><html><object width="640" height="480"><param name="movie" value="http://www.youtube.com/v/hEfjD3TNE6A?version=3&amp;hl=zh_TW"></param><param name="allowFullScreen" value="true"></param><param name="allowscriptaccess" value="always"></param><embed src="http://www.youtube.com/v/hEfjD3TNE6A?version=3&amp;hl=zh_TW" type="application/x-shockwave-flash" width="640" height="480" allowscriptaccess="always" allowfullscreen="true"></embed></object></html>
+</center>
+=='''<font size=4><font color=green>Summary of Our Achievements</font></font>'''==
+<font size=3>
+<center>[[image:Achievement.png|900px|]]</center>
+</font>
+=='''<font size=4><font color=green>Our Institute</font></font>'''==
+<font size=4 color=mediumblue>'''(1) The official web sites of our school - National Yang Ming University (NYMU):'''</font>
+[http://web.ym.edu.tw/front/bin/home.phtml <font size=3 color=black><u>in Chinese</u></font>]
+[http://nymu-e.web.ym.edu.tw/front/bin/home.phtml <font size=3 color=black><u>in English</u></font>]
+<font size=4 color=mediumblue>'''(2) Follow the two links below to see The Beauty of NYMU'''</font>
+[http://issue.ym.edu.tw/cia/new/ <font size=3 color=black><u>Take a panoramic scenery view of our university</u></font>]
+[http://issue.ym.edu.tw/cia/new/tw/ym720.html <font size=3 color=black><u>Take a tour of our university</u></font>]
+<center>[[file:nymutaipei2.jpg|400px|]]</center>
+<center>[[Image:Sponsor 2011igem NYMU-Taipei.png]]</center>