Team:Groningen

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=<center>Welcome to the iGEM 2011 Groningen team page</center>=
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<span style="font-size: 1.5em">Welcome to the iGEM 2011 Groningen team page</span>
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==Count coli - a synthetic biological counter==
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Our team is based at the University of Groningen in the Netherlands.
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<html><center><div style="width: 500px; text-align: justify">Our project aims to design a genetic device able to count and memorize the occurrences of an input signal. We achieved this by utilizing auto-inducing loops that act as memory units, and an engineered riboregulator acting as an AND gate. This design of the device is modular allowing free change of both input and output signals. Each increase of the counter results in a different output signal. The design allows implementation of any number of memory units, as the AND gate design enables us to extend the system in a hassle-free way. In order to tweak bistable autoinducing loops we needed a very fast and robust method for characterizing parts. For this we have created a cloud based application hosting a genetic algorithm. It also allows the combination of data from multiple experiments across models with overlapping components. This functionality, massively parallelized on the cloud and backed by our own pool of clients, allowed us to find parameters of the parts used in the design.
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<span style="font-size: 1.2em; color: #c00">Our project</span>
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'''Our engineered biological abacus counts occurrences of cold shocks.'''
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[[File:GroningenComic.png|center|500px|]]
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[[Groningen2011_project|Read more about our project!]]
 
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<center>'''Our team is based at the University of Groningen in the Netherlands'''</center>
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<a href="https://2011.igem.org/Team:Groningen/team_overview" onMouseOver="document.groupphoto.src='https://static.igem.org/mediawiki/2011/4/45/TeamGroningenPhoto2.jpg';" onMouseOut="document.groupphoto.src='https://static.igem.org/mediawiki/2011/3/37/TeamGroningenPhoto3.jpg';">
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<center>(hover your cursor over our team picture for a friendly hello)</center>
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<span style="font-size: 1.2em">Team members:</span>
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|[[File:Kuba.jpg]]
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Jakub Radzikowski
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''chairman''
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|[[File:Olesja.jpg]]
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Olesja Popow
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''secretary''
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|[[File:Jaap.jpg]]
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Jaap Oosterbroek
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''modeling officer''
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|[[File:Christoph.png]]
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Christoph Wittich
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''treasurer''
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Joyce Mulder
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''human practices''
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Rodrigo Perez
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''sponsoring officer''
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|[[File:Jori.jpg]]
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Jori Huisman
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''IT officer''
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|[[File:Berke.jpg]]
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Berke Gurkan
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Navessa Padma Tania
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<span style="font-size: 1.2em; color: #c00">Our supervisors:</span>
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[[File:oscar.png]]
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prof. Oscar Kuipers, head of the Molecular Genetics research group
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prof. Matthias Heinemann, head of the Molecular Systems Biology research group
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dr. Jan Willem Veening, assistant professor at the Molecular Genetics research group
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<span style="font-size: 1.2em; color: #c00">Contact information:</span>
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[mailto:team@igemgroningen.com team@igemgroningen.com]
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[[Modeling|Modeling main page]]
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!align="center"|[[Team:Groningen|Home]]
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!align="center"|[[Team:Groningen/Team|Team]]
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!align="center"|[https://igem.org/Team.cgi?year=2011&team_name=Groningen Official Team Profile]
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!align="center"|[[Team:Groningen/Project|Project]]
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!align="center"|[[Team:Groningen/Parts|Parts Submitted to the Registry]]
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!align="center"|[[Team:Groningen/Modeling|Modeling]]
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!align="center"|[[Team:Groningen/Notebook|Notebook]]
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!align="center"|[[Team:Groningen/Safety|Safety]]
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!align="center"|[[Team:Groningen/Attributions|Attributions]]
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Latest revision as of 08:58, 28 October 2011


Welcome to the iGEM 2011 Groningen team page

Count coli - a synthetic biological counter

Our project aims to design a genetic device able to count and memorize the occurrences of an input signal. We achieved this by utilizing auto-inducing loops that act as memory units, and an engineered riboregulator acting as an AND gate. This design of the device is modular allowing free change of both input and output signals. Each increase of the counter results in a different output signal. The design allows implementation of any number of memory units, as the AND gate design enables us to extend the system in a hassle-free way. In order to tweak bistable autoinducing loops we needed a very fast and robust method for characterizing parts. For this we have created a cloud based application hosting a genetic algorithm. It also allows the combination of data from multiple experiments across models with overlapping components. This functionality, massively parallelized on the cloud and backed by our own pool of clients, allowed us to find parameters of the parts used in the design.


Our engineered biological abacus counts occurrences of cold shocks.

GroningenComic.png


Our team is based at the University of Groningen in the Netherlands

(hover your cursor over our team picture for a friendly hello)



Retrieved from "http://2011.igem.org/Team:Groningen"