Team:UT Dallas

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</html>{{:Team:UT_Dallas/Template:links}}<html>
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      <h1><a href="index.html"><span>UTDallas </span> iGem 2011<small></small></a></h1>
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        <h3>Creating Futures</h3>
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          <h2><span><b>UT Dallas iGem 2011: Project Description</b></span></h2>
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<h2>Immunobots: a step towards intelligent probiotics</h2>
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<br>
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<table width="720">
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<tr><td valign="top" >
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The human bowel hosts a rich diversity of symbiotic microflora that provides a powerful
 +
engineering platform for intelligent probiotics. These immunobots will ideally work in-sync
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and enhance natural self-repair mechanisms for a range of intestinal diseases associated with
 +
tissue damage.<br><br>Towards this end, we engineered a bacterial chemotaxis pathway that utilizes a
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chimeric receptor to successfully interface with the immune system (<b>immunobot</b>). In addition, we introduced
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an inducible secondary bacterial population that can trigger system-wide self-destruction,
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conferring an additional level of user control (<b>killbot</b>). Each module of our system was characterized
 +
using fluorescent reporters and the integrated parts were evaluated by controlled experiments
 +
involving wound signal gradients.<br><br>We envision a probiotic solution that can facilitate localized
 +
tissue repair for damage resulting from inflammatory bowel diseases, including ulcerative colitis
 +
and Crohn’s disease.</td>
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<td valign="top">
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Latest revision as of 03:29, 29 September 2011

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