Team:Queens Canada/Project/Future
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<regulartext> At the beginning of the summer we decided to work with <i>C. elegans</i> as our chassis, mostly for the advantages provided by its advanced eukaryotic chemotaxis mechanism. However, as the summer progressed and we learned more about the worm, it proved to be a very shrewd choice. One feature of the worm that we found in working with it was its amazing resilience to harsh environments. Chemotaxis assays done with undiluted naphthalene did not kill or paralyze all of the worms and even allowed for chemotaxis in some! Hardiness of this magnitude was not at all what we were expecting from a 1mm long nematode. We even found the worms able to survive in bitumen straight from tailing ponds for at least a week. Further exploration into the bioremediative potential and capabilities of <i>C. elegans</i> in oil spills is warranted given <i>C. elegans’</i> innate chemotaxis mechanisms towards aromatics, such as those found in bitumen, as well as its resilience to harsh tailing pond conditions.</regulartext> | <regulartext> At the beginning of the summer we decided to work with <i>C. elegans</i> as our chassis, mostly for the advantages provided by its advanced eukaryotic chemotaxis mechanism. However, as the summer progressed and we learned more about the worm, it proved to be a very shrewd choice. One feature of the worm that we found in working with it was its amazing resilience to harsh environments. Chemotaxis assays done with undiluted naphthalene did not kill or paralyze all of the worms and even allowed for chemotaxis in some! Hardiness of this magnitude was not at all what we were expecting from a 1mm long nematode. We even found the worms able to survive in bitumen straight from tailing ponds for at least a week. Further exploration into the bioremediative potential and capabilities of <i>C. elegans</i> in oil spills is warranted given <i>C. elegans’</i> innate chemotaxis mechanisms towards aromatics, such as those found in bitumen, as well as its resilience to harsh tailing pond conditions.</regulartext> | ||
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<regulartext>When working with chemotaxis mechanisms in <i> C. elegans</i> it seems the only limiting factor is finding GPCRs that bind to your target ligand. Having the common traits of being eukaryotic and multicellular with a variety of species, grants <i>C. elegans</i> an immense number of sources of potential GPCRs. The capactiy to express human genes coding for GPCRs in <i>C. elegans</i> can allow for future teams to program the worm to respond to stimuli recognized by human GPCRs. This would likely prove to be a worthwhile endeavor. </regulartext> | <regulartext>When working with chemotaxis mechanisms in <i> C. elegans</i> it seems the only limiting factor is finding GPCRs that bind to your target ligand. Having the common traits of being eukaryotic and multicellular with a variety of species, grants <i>C. elegans</i> an immense number of sources of potential GPCRs. The capactiy to express human genes coding for GPCRs in <i>C. elegans</i> can allow for future teams to program the worm to respond to stimuli recognized by human GPCRs. This would likely prove to be a worthwhile endeavor. </regulartext> | ||
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<h3red> Eukaryotic iGEM </h3red><p> | <h3red> Eukaryotic iGEM </h3red><p> | ||
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<h3red> GPCRs </h3red><p> | <h3red> GPCRs </h3red><p> | ||
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Latest revision as of 22:45, 28 October 2011