Team:Grenoble/Projet/Results

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<div class="left">
<div class="left">
<div  class="blocbackground" id="Achievements">
<div  class="blocbackground" id="Achievements">
    <h1>Achievements</h1>
    <h1>Achievements</h1>
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    <p>
 
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On this page you can find the achievements of our project.
 
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</p>
 
     </div>
     </div>
<div  class="blocbackground" id="Content">
<div  class="blocbackground" id="Content">
<h2>Table of content</h2>
<h2>Table of content</h2>
<p>
<p>
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For a better understanding, we divided the results into several parts.
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We describe here the modeling and experimental results obtained for each network module,
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in order to validate our model and optimize the device: the toggle switch, the quorum sensing
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and the translational regulation system RsmA.  
<ol>
<ol>
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<li>The toggle switch</li>
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<li>Validation of the genetic network</li>
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<li>The quorum sensing</li>
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<li>The essential role of rmsA regulation system</li>
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<li>the translationnal regulation system rsmA</li>
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<li>Device optimization and specifications</li>
</ol>
</ol>
In each part, we tried to speak about both experiment and modelling, in order to validate our model and optimized  
In each part, we tried to speak about both experiment and modelling, in order to validate our model and optimized  
by simulation the device.<br/><br/>
by simulation the device.<br/><br/>
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  <a href="https://2011.igem.org/Team:Grenoble/Projet/Results/Toggle" ><img class="icon" src="https://static.igem.org/mediawiki/2011/3/38/Image2993.png"/></a>
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  <a href="https://2011.igem.org/Team:Grenoble/Projet/Results/Toggle" ><img class="icon" src="https://static.igem.org/mediawiki/2011/2/20/Bouton_toggle.png"/></a>
     
     
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      <big><big><a href="https://2011.igem.org/Team:Grenoble/Projet/Results/Toggle" class="menu">Toggle Switch</a></big></big><br/>
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      <big><big><a href="https://2011.igem.org/Team:Grenoble/Projet/Results/Toggle" class="menu">Validation of the network</a></big></big><br/>
       
       
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<a class="menu" href="https://2011.igem.org/Team:Grenoble/Projet/Results/Toggle#Construction">Construction of the toggle switch</a><br/>
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<a class="menu" href="https://2011.igem.org/Team:Grenoble/Projet/Results/Toggle#TS_QS">Toggle Switch and Quorum sensing behavior</a><br/>
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<a class="menu" href="https://2011.igem.org/Team:Grenoble/Projet/Results/Toggle#Validation">Validation of the model</a><br/><br/><br/><br/>
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<a class="menu" href="https://2011.igem.org/Team:Grenoble/Projet/Results/Toggle#Validation">Validation of the model</a><br/>
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<a class="menu" href="https://2011.igem.org/Team:Grenoble/Projet/Results/Toggle#Dynamic">Dynamic study of the stability</a><br/><br/><br/>
       
       
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  <a href="https://2011.igem.org/Team:Grenoble/Projet/Results/Quorum"><img class="icon" src="https://static.igem.org/mediawiki/2011/0/0a/Image3030.png"/></a>
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  <a href="https://2011.igem.org/Team:Grenoble/Projet/Results/rmsA" ><img class="icon" src="https://static.igem.org/mediawiki/2011/9/97/Bouton_regulation.png"/></a>
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<big><big><a class="menu" href="https://2011.igem.org/Team:Grenoble/Projet/Results/Quorum">Quorum Sensing</a></big></big><br/>
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<a class="menu" href="https://2011.igem.org/Team:Grenoble/Projet/Results/Quorum#Simulation">Optimization of the device</a><br/>
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<a class="menu" href="https://2011.igem.org/Team:Grenoble/Projet/Results/Quorum#Experiment">Test of the quorum sensing system</a><br/><br/><br/><br/>
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  <a href="https://2011.igem.org/Team:Grenoble/Projet/Results/rmsA" ><img class="icon" src="https://static.igem.org/mediawiki/2011/6/6e/Icon_rsma.png"/></a>
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<br/><big><big><a href="https://2011.igem.org/Team:Grenoble/Projet/Results/rmsA" class="menu">Post-transcriptional regulation :</a></big></big><br/><br/><br/><br/>
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<big><big><a href="https://2011.igem.org/Team:Grenoble/Projet/Results/rmsA" class="menu">The essential role of rsmA regulation system</a></big></big><br/>
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<a class="menu" href="https://2011.igem.org/Team:Grenoble/Projet/Results/rmsA#Necessity">Why do we need this system ?</a><br/>
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<a class="menu" href="https://2011.igem.org/Team:Grenoble/Projet/Results/rmsA#fha">Leader sequence characterization</a><br/>
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<a class="menu" href="https://2011.igem.org/Team:Grenoble/Projet/Results/rmsA#rsma">rsmA characterization</a><br/><br/><br/>
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  <a href="https://2011.igem.org/Team:Grenoble/Projet/Results/Device" ><img class="icon" src="https://static.igem.org/mediawiki/2011/7/70/Bouton_general_modeling.png"/></a>
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<big><big><a href="https://2011.igem.org/Team:Grenoble/Projet/Results/Device" class="menu">Device specificities and optimization</a></big></big><br/>
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<a class="menu" href="https://2011.igem.org/Team:Grenoble/Projet/Results/Device#Optimization">Optimization of the device</a><br/>
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<a class="menu" href="https://2011.igem.org/Team:Grenoble/Projet/Results/Device#Limit">Determination of the limit of quantification</a><br/>
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<a class="menu" href="https://2011.igem.org/Team:Grenoble/Projet/Results/Device#Statistic">Stochastic study for statistic determination of several device specificities</a><br/><br/><br/>
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  <a href="https://2011.igem.org/Team:Grenoble/Projet/Results/Sensitivity" ><img class="icon" src="https://static.igem.org/mediawiki/2011/f/fd/Bouton_model_sensitivity.png"/></a>
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<big><big><a href="https://2011.igem.org/Team:Grenoble/Projet/Results/Sensitivity" class="menu">Sensitivity to parameters study</a></big></big><br/>
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<a class="menu" href="https://2011.igem.org/Team:Grenoble/Projet/Results/Sensitivity#Robustness">Robustness of our system</a><br/>
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<a class="menu" href="https://2011.igem.org/Team:Grenoble/Projet/Results/Sensitivity#Mercury">Applicable to mercury</a><br/><br/><br/><br/>
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    </p>
    </p>
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<center>
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<form method="get" >
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  <input type="button" value="< PREVIOUS <" onclick="document.location = '/Team:Grenoble/Projet/Results';" />
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  <select name="id" onchange="document.location = '/Team:Grenoble/Projet/Results' + this.options[this.selectedIndex].value ;">
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    <optgroup label="Table of content">
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    <option value="#Content" selected="selected">Table of content</option>
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    </optgroup>
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 +
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    <optgroup label="Toggle Switch" >
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                                    <option value="/Toggle#TS_QS" >Toggle Switch and Quorum Sensing</option>
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                                    <option value="/Toggle#Validation" >Validation of the model</option>
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                                    <option value="/Toggle#Dynamic" >Dynamic study of the stability</option>
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                            </optgroup>
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                            <optgroup label="Post-transcriptional regulation (RsmA)">
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                                    <option value="/rmsA#Necessity">Necessity of this system</option>
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                                    <option value="/rmsA#fha">Leader sequence characterization</option>
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                                    <option value="/rmsA#rsma">rsmA characterization</option>
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 +
                                   
 +
                               
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                            </optgroup>
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                            <optgroup label="Device">
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    <option value="/Device#Optimization" >Optimization of the device</option>
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    <option value="/Device#Limit">Determination of the limit of quantification</option>
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    <option value="/Device#Statistic">Statistic study of device specificities</option>
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    </optgroup>
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                            <optgroup label="Sensitivity to parameters">
 +
                           
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    <option value="/Sensitivity#Robustness">Robustness of the system</option>
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    <option value="/Sensitivity#Mercury">Applicable to mercury</option>
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    </optgroup>
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                    </select>
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                    <input type="hidden" name="id2" value="0" />
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                    <input type="submit" value="Go!" />
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  <input type="button" value="> NEXT >" onclick="document.location = '/Team:Grenoble/Projet/Results/Toggle';" />
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</form>
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</center>
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{{:Team:Grenoble/Design/pied}}

Latest revision as of 03:20, 29 October 2011

Grenoble 2011, Mercuro-Coli iGEM


Achievements

Table of content

We describe here the modeling and experimental results obtained for each network module, in order to validate our model and optimize the device: the toggle switch, the quorum sensing and the translational regulation system RsmA.

  1. Validation of the genetic network
  2. The essential role of rmsA regulation system
  3. Device optimization and specifications
In each part, we tried to speak about both experiment and modelling, in order to validate our model and optimized by simulation the device.

Validation of the network
Toggle Switch and Quorum sensing behavior
Validation of the model
Dynamic study of the stability


The essential role of rsmA regulation system
Why do we need this system ?
Leader sequence characterization
rsmA characterization


Device specificities and optimization
Optimization of the device
Determination of the limit of quantification
Stochastic study for statistic determination of several device specificities


Sensitivity to parameters study
Robustness of our system
Applicable to mercury



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