Team:NYMU-Taipei

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=<font size=5><font color=crimson>'''Tailoring Your Avatar'''</font></font>=
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You are provided with this team page template with which to start the iGEM season.  You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki.  You can find some examples <a href="https://2009.igem.org/Help:Template/Examples">HERE</a>.
 
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You <strong>MUST</strong> have a team description page, a project abstract, a complete project description, a lab notebook, and a safety page.  PLEASE keep all of your pages within your teams namespace. 
 
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=='''<font size=4><font color=green>Goal</font></font>'''==
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|You can write a background of your team here.  Give us a background of your team, the members, etc.  Or tell us more about something of your choosing.
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<font size=3>Create <b>wireless neuro-stimulator</b>, focusing on achieving remote neuro-stimulation to minimize invasion and damage to the neuron.</font>
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|[[Image:NYMU-Taipei_logo.png|200px|right|frame]]
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''Tell us more about your project.  Give us background.  Use this as the abstract of your project.  Be descriptive but concise (1-2 paragraphs)''
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|[[Image:NYMU-Taipei_team.png|right|frame|Your team picture]]
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=='''<font size=4><font color=green>Why Do We Want to Do That?</font></font>==
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<font size=3><b>Optogenetics</b>, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved. </font>
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=='''<font size=4><font color=green>Specific Aims</font></font>'''==
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<font size=4><font color=mediumblue>'''(1) Wireless stimulation for neurons'''</font></font>
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<font size=4><font color=mediumblue>'''(2) Minimization of neuro-immuno response'''</font></font>
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=='''<font size=4 color=green>Our Design</font>'''==
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!align="center"|[[Team:NYMU-Taipei|Home]]
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!align="center"|[[Team:NYMU-Taipei/Team|Team]]
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To achieve this goal, we use a species of magnetic bacterium,'' Magnetospirillum magneticum'' AMB-1. We have chosen <b>mms13</b>, a transmembrane protein as our target for protein design in this bacterium, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we have utilized three genes to achieve <b>neurosymbiosis</b> within glial cells: <b>''MinC''</b>, a division inhibitor, <b>''INV''</b>, a gene for invasion and <b>''LLO''</b>, a gene for facilitating escapes from phagosomes.</font>
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!align="center"|[https://igem.org/Team.cgi?year=2011&team_name=NYMU-Taipei Official Team Profile]
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!align="center"|[[Team:NYMU-Taipei/Project|Project]]
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'''<font size=3>Our design is made up of the following two devices:</font>'''
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!align="center"|[[Team:NYMU-Taipei/Parts|Parts Submitted to the Registry]]
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!align="center"|[[Team:NYMU-Taipei/Modeling|Modeling]]
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[https://2011.igem.org/Team:NYMU-Taipei/optomagnetic-design <font size=4><font color=mediumblue>'''(1) <u>Optomagnetic Design</u>'''</font></font>]
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!align="center"|[[Team:NYMU-Taipei/Notebook|Notebook]]
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!align="center"|[[Team:NYMU-Taipei/Safety|Safety]]
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<font size=3>Bridging magnetics and optogenetics.</font>
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!align="center"|[[Team:NYMU-Taipei/Attributions|Attributions]]
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[https://2011.igem.org/Team:NYMU-Taipei/immunological-solution <font size=4><font color=mediumblue>'''(2)<u> NeuroSymbiosis</u>'''</font></font>]
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<font size=3>Enabling magnetotactic bacteria to be neurosymbiosis with glia cells.</font>
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=='''<font size=4><font color=green>3D Deep Brain Stimulation model</font></font>'''==
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=='''<font size=4><font color=green>Summary of Our Achievements</font></font>'''==
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<center>[[image:Achievement.png|900px|]]</center>
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=='''<font size=4><font color=green>Our Institute</font></font>'''==
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<font size=4 color=mediumblue>'''(1) The official web sites of our school - National Yang Ming University (NYMU):'''</font>
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[http://web.ym.edu.tw/front/bin/home.phtml <font size=3 color=black><u>in Chinese</u></font>]
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[http://nymu-e.web.ym.edu.tw/front/bin/home.phtml <font size=3 color=black><u>in English</u></font>]
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<font size=4 color=mediumblue>'''(2) Follow the two links below to see The Beauty of NYMU'''</font>
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[http://issue.ym.edu.tw/cia/new/ <font size=3 color=black><u>Take a panoramic scenery view of our university</u></font>]
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[http://issue.ym.edu.tw/cia/new/tw/ym720.html <font size=3 color=black><u>Take a tour of our university</u></font>]
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<center>[[file:nymutaipei2.jpg|400px|]]</center>
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<center>[[Image:Sponsor 2011igem NYMU-Taipei.png]]</center>

Latest revision as of 03:12, 7 December 2011

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Contents

Tailoring Your Avatar

Goal

Create wireless neuro-stimulator, focusing on achieving remote neuro-stimulation to minimize invasion and damage to the neuron.

Why Do We Want to Do That?

Optogenetics, the latest neuroscientific method, has improved specificity for stimulating certain cell types of neurons, reversible bi-directional stimulation, and elevated spatiotemporal precision. However, to achieve neuronal network stimulation, light cables are still needed, leaving long-standing annoying issues regarding immune responses unresolved.


Specific Aims

(1) Wireless stimulation for neurons

(2) Minimization of neuro-immuno response

Our Design

To achieve this goal, we use a species of magnetic bacterium, Magnetospirillum magneticum AMB-1. We have chosen mms13, a transmembrane protein as our target for protein design in this bacterium, as it serves as a linker between reception of wireless magnetic field and optogenetic neuro-stimulation output. Regarding the neuroimmune response, we have utilized three genes to achieve neurosymbiosis within glial cells: MinC, a division inhibitor, INV, a gene for invasion and LLO, a gene for facilitating escapes from phagosomes.

Our design is made up of the following two devices:

(1) Optomagnetic Design

Bridging magnetics and optogenetics.

(2) NeuroSymbiosis

Enabling magnetotactic bacteria to be neurosymbiosis with glia cells.

3D Deep Brain Stimulation model

Summary of Our Achievements

Achievement.png

Our Institute

(1) The official web sites of our school - National Yang Ming University (NYMU):

[http://web.ym.edu.tw/front/bin/home.phtml in Chinese]

[http://nymu-e.web.ym.edu.tw/front/bin/home.phtml in English]

(2) Follow the two links below to see The Beauty of NYMU

[http://issue.ym.edu.tw/cia/new/ Take a panoramic scenery view of our university]

[http://issue.ym.edu.tw/cia/new/tw/ym720.html Take a tour of our university]

Nymutaipei2.jpg


Sponsor 2011igem NYMU-Taipei.png
Retrieved from "http://2011.igem.org/Team:NYMU-Taipei"