Team:Northwestern

From 2011.igem.org

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|You can write a background of your team here.  Give us a background of your team, the members, etc.  Or tell us more about something of your choosing.
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<div style="margin: -50px 0px 0px 120px;font:35px helvetica; color:#ffffff;"> Abstract
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<center>'''My N.U. P.A.L'''<br>'''Northwestern University's ''Pseudomonas aeruginosa'' Locator'''</center><br>
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''Pseudomonas aeruginosa'' is an opportunistic pathogen commonly found in immunocompromised patients. In addition to being the primary cause of lung infections in cystic fibrosis patients, many severe nosocomial infections can be attributed to ''P. aeruginosa''. Currently, the standard detection method requires a potential sample to be grown overnight and then screened for the pathogen of interest. We have engineered an ''E. coli''-based biosensor capable of detecting the presence of autoinducer molecules unique to ''P. aeruginosa''. Thus, our system provides a faster detection method without sacrificing reliability or experimental resolution. Quorum sensing in ''P. aeruginosa'' is a complex hierarchy that governs the expression of numerous virulence genes. To realize our objective, we harnessed the native cell signaling and quorum sensing machinery of ''P. aeruginosa''. We have thus created a novel, inexpensive biosensor capable of detecting the presence of ''P. aeruginosa'' both quickly and effectively.
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!align="center"|[[Team:Northwestern|Home]]
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!align="center"|[[Team:Northwestern/Team|Team]]
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!align="center"|[https://igem.org/Team.cgi?year=2011&team_name=Northwestern Official Team Profile]
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!align="center"|[[Team:Northwestern/Project|Project]]
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!align="center"|[[Team:Northwestern/Parts|Parts Submitted to the Registry]]
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!align="center"|[[Team:Northwestern/Modeling|Modeling]]
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!align="center"|[[Team:Northwestern/Notebook|Notebook]]
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!align="center"|[[Team:Northwestern/Safety|Safety]]
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!align="center"|[[Team:Northwestern/Attributions|Attributions]]
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==Sponsorship==
 
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[[Image:Sponsor_northwestern.jpg]]
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[[Image:Sponsor_weinberg.jpg]]
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&nbsp; &nbsp; &nbsp; &nbsp;iGEM Workers Researching on a Crossbeam 1932
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<div style="text-align:right; font-size:15px;">(Based on the original <a href="https://static.igem.org/mediawiki/2011/4/4a/Construction_Workers.jpg"><i>Construction Workers Lunching on a Crossbeam</i></a>)
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Latest revision as of 02:02, 29 October 2011

RETURN TO IGEM 2010


iGEM_NU
    twitter


    My N.U. P.A.L
    Northwestern University's Pseudomonas aeruginosa Locator

    Pseudomonas aeruginosa is an opportunistic pathogen commonly found in immunocompromised patients. In addition to being the primary cause of lung infections in cystic fibrosis patients, many severe nosocomial infections can be attributed to P. aeruginosa. Currently, the standard detection method requires a potential sample to be grown overnight and then screened for the pathogen of interest. We have engineered an E. coli-based biosensor capable of detecting the presence of autoinducer molecules unique to P. aeruginosa. Thus, our system provides a faster detection method without sacrificing reliability or experimental resolution. Quorum sensing in P. aeruginosa is a complex hierarchy that governs the expression of numerous virulence genes. To realize our objective, we harnessed the native cell signaling and quorum sensing machinery of P. aeruginosa. We have thus created a novel, inexpensive biosensor capable of detecting the presence of P. aeruginosa both quickly and effectively.




           iGEM Workers Researching on a Crossbeam 1932 group



    Sponsor northwestern.jpg Sponsor weinberg.jpg Sponsor mccormick.jpg