Team:UT Dallas

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|align="center"|[[Team:UT_Dallas | Team Example]]
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!align="center"|[[Team:UT_Dallas|Home]]
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!align="center"|[[Team:UT_Dallas/Team|Team]]
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!align="center"|[[Team:UT_Dallas/Modeling|Modeling]]
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!align="center"|[[Team:UT_Dallas/Notebook|Notebook]]
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!align="center"|[[Team:UT_Dallas/Human_Practices|Human Practices]]
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<h2>Immunobots: a step towards intelligent probiotics</h2>
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!align="center"|[[Team:UT_Dallas/Attributions|Attributions]]
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The human bowel hosts a rich diversity of symbiotic microflora that provides a powerful
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engineering platform for intelligent probiotics. These immunobots will ideally work in-sync
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and enhance natural self-repair mechanisms for a range of intestinal diseases associated with
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tissue damage.<br><br>Towards this end, we engineered a bacterial chemotaxis pathway that utilizes a
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chimeric receptor to successfully interface with the immune system (<b>immunobot</b>). In addition, we introduced
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an inducible secondary bacterial population that can trigger system-wide self-destruction,
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conferring an additional level of user control (<b>killbot</b>). Each module of our system was characterized
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using fluorescent reporters and the integrated parts were evaluated by controlled experiments
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involving wound signal gradients.<br><br>We envision a probiotic solution that can facilitate localized
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tissue repair for damage resulting from inflammatory bowel diseases, including ulcerative colitis
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and Crohn’s disease.</td>
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Latest revision as of 03:29, 29 September 2011

Retrieved from "http://2011.igem.org/Team:UT_Dallas"