Team:CBNU-Korea/Safety

From 2011.igem.org

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Latest revision as of 10:48, 29 September 2011

a. The software, the genome database, and the genome design tool which we plan to use are already in public domain. Therefore we do not need to establish additional limited access for biosecurity.
b. Our database has only essential gene data that the organism must have for survival. The information will be obtained from the DEG database (http://tubic.tju.edu.cn/deg/). In addition most pathogenic genes are not essential genes. In case any pathogenic gene is included in the essential genes, we will establish limited access of gene database for biosecurity. There is no domestic regulation in Korea on obtaining the sequence of pathogenic genes.
c. In order to prevent any intentional abuse of pathogenic gene information (if which are included in this study), first, we will not make a disclosure of pathogenic or toxin gene data to our database. Second, the genome design tool developed will be released only with an official request from the head of the organization or department which should include nation, affiliation, group, name of PI, purpose, address, contact information (address, telephone, e-mail), etc. .

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-To design the Synthetic Minimal Chromosome of a bacterium, that the information on essential genes, such as direction, position, length and function, is essential. In addition a new analyzing method which calculates the distance between replication origin and each essential gene (DTO; Distance to origin) in each species, and provides the number of essential genes within 10 percent of total genome size are required. Using this method, we confirmed a distribution of essential genes in each organism.<br>
+<u><b>a</b></u>. The software, the genome database, and the genome design tool which we plan to use are already in public domain. Therefore we do not need to establish additional limited access for biosecurity.<br>
-In this study the information of essential genes will be obtained from DEG (Database of Essential Genes). We will re-group essential genes by COG distribution for construction of our database which is connected to a software named GOD (Genome Organization Database & Designer).
+<u><b>b</b></u>. Our database has only essential gene data that the organism must have for survival. The information will be obtained from the DEG database (<a href="http://tubic.tju.edu.cn/deg/" target="_blank">http://tubic.tju.edu.cn/deg/</a>). In addition most pathogenic genes are not essential genes. In case any pathogenic gene is included in the essential genes, we will establish limited access of gene database for biosecurity. There is no domestic regulation in Korea on obtaining the sequence of pathogenic genes.<br>
+<u><b>c</b></u>. In order to prevent any intentional abuse of pathogenic gene information (if which are included in this study), first, we will not make a disclosure of pathogenic or toxin gene data to our database. Second, the genome design tool developed will be released only with an official request from the head of the organization or department which should include nation, affiliation, group, name of PI, purpose, address, contact information (address, telephone, e-mail), etc. .
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