Team:Queens Canada/Project/Rationale
From 2011.igem.org
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+ | <regulartext> | ||
+ | <span class="classred"><a href="#bio">bioremediation </a></span> </regulartext> | ||
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+ | <span class="classred"><a href="#euk">eukaryotic </a></span> </regulartext> | ||
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+ | <span class="classred"><a href="#elegans"> <i>C. elegans </i> </a></span> </regulartext> | ||
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- | < | + | <h3red> Why Bioremediation? </h3red><p> |
- | <regulartext> The QGEM 2011 team | + | <img align="left" style="margin-bottom:0px; width: 735px; margin-top:3px; padding:5;" src="https://static.igem.org/mediawiki/2011/1/1d/Oilsands.jpg"> |
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+ | <regulartext> As conventional sources of oil are depleted, there is a demand for petroleum products from other sources. Novel technologies have made once non-economic extraction methods much simpler and cost-effective. A region of explosive growth is in Oil Sands, a resource home to Western Canada. </regulartext><p> | ||
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+ | <regulartext>As the Albertan Oil Sands ( continue to be developed, companies will face significant environmental remediation challenges. In order to ensure the preservation of the environment, novel strategies to find and degrade the toxic by-products of bitumen processing must be implemented.</regulartext><p> | ||
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+ | <regulartext> The QGEM 2011 team was largely motivated by successes such as the use of the bacterium <i>Pseudomonas putida</i> in bioremediation, which proved that microbial biodegradation of environmental pollutants is a viable possibility. However, we wished to push the boundaries further, by creating a multicellular eukaryotic organism which could chemotax towards and breakdown certain types of pollutants. The potential for this kind of organism would be great, as it would have a broader travel range than microbes, would be generally safe to use, and could be applied to field assay tests (such as tests for toxins). </regulartext><p> | ||
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+ | <h3red> Why an Eukaryotic Organism? </h3red><p> | ||
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+ | <regulartext> Our team isn't the first to genetically engineer a bioremediation solution. And we certainly won't be the last. <p> </regulartext> | ||
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+ | <regulartext> Many iGEM teams have developed projects that: </regulartext><br> | ||
+ | <regulartext>- Have a biosensor for toxic or polluting chemicals, </regulartext><br> | ||
+ | <regulartext>- Can degrade hydrocarbons, </regulartext><br> | ||
+ | <regulartext>- Contain a genetic kill switch to prevent. </regulartext><p> | ||
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+ | <regulartext> For our 2011 project, we wouldn't to design one organism that could accomplish these tasks, as well as move towards a contaminated site. </regulartext><p> | ||
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+ | <img align="left" style="margin-bottom:0px; width: 755px; margin-top:-3px; padding:0;" src="https://static.igem.org/mediawiki/2011/b/b2/Queens_CanadaFlowChart.png"><p> | ||
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+ | <regulartext> Such sophistication would require the unique toolbox of an eukaryotic organism. </regulartext> | ||
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+ | <h3red> Why Use a Worm? </h3red><p> | ||
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+ | <regulartext> Currently there are effective bacterial systems for the degradation of many toxic by-products, but these bacteria cannot move significant distances in the environment to seek out their bio-degradation substrates. The nematode worm <i>Caenorhabditis elegans’</i> has many advantages: </regulartext><p> | ||
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+ | <regulartext><b>Chemotaxis Movement-</b>Robust chemotaxis network represents a system that can be engineered for the detection and long-range movement towards environmental toxins </regulartext><p> | ||
+ | <regulartext><b>Multi-Cellular=Multiple Processes-</b> As a eukaryote, many processes can be included at the same time in multiple lcoations. </regulartext><p> | ||
+ | <regulartext><b>Hardy Organism-</b> Preliminary tests showed <i> C. elegans </i> able to live in pure bitumen (from Oil Sands) for over a week.</regulartext><p> | ||
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Latest revision as of 03:11, 29 October 2011