Team:NYC Wetware/BioNumbers

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Deinococcus Radioduran (D. rad) is famous for being resistant to 3000 times the radiation dose lethal to humans.  Inspired to prove the potential of genetic engineering, the New York City iGEM Team chose to create radiation-resistant biobricks. We planned to find the genes that give D. rad extraordinary radiation resistance, and put them into loserish bacteria like E. coli, and see if we could turn the E. coli into super-hero bacteria.<br/>  
Deinococcus Radioduran (D. rad) is famous for being resistant to 3000 times the radiation dose lethal to humans.  Inspired to prove the potential of genetic engineering, the New York City iGEM Team chose to create radiation-resistant biobricks. We planned to find the genes that give D. rad extraordinary radiation resistance, and put them into loserish bacteria like E. coli, and see if we could turn the E. coli into super-hero bacteria.<br/>  
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By finding genes that allow life to thrive in extremely harsh environments, we help develop the emerging field of genetic engineering into a classic engineering disciplines like electrical and mechanical engineering. We will demonstrated that we too can tackle the complex problems. Below find a table of extremophile values. Achieve these and demonstrate the power of synthetic biology to yourselves, fellow iGEM teams, fellow engineers and the general public. In addition to the list below, we have submitted these values to the <a href="http://bionumbers.hms.harvard.edu/">BioNumbers</a> database, of Harvard Medical School and Weizmann Institute. Good Luck!
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By finding genes that allow life to thrive in extremely harsh environments, we help develop the emerging field of genetic engineering into a classic engineering discipline like electrical or mechanical engineering. We will demonstrated that we too can tackle the complex problems. Below find a table of extremophile values. Achieve these and demonstrate the power of synthetic biology to yourselves, fellow iGEM teams, fellow engineers and the general public. In addition to the list below, we have submitted these values to the <a href="http://bionumbers.hms.harvard.edu"> BioNumbers</a> Database. Good Luck!<br/>
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<ol>High Radiation:  Deinocuccus radiodurans can live in 15000 Gy<br/>
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Low Temperature:  Arthrobacter can live in < -15 celsius<br/>
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<b>Extremophile Numbers</b><br/>
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High Radiation:  Deinocuccus radiodurans can live in 17500 Gy<br/>
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Low Temperature:  Assorted Bacteria can live in < 1 celsius<br/>
High Temperature:  Strain 121 can live in 130 celsius<br/>
High Temperature:  Strain 121 can live in 130 celsius<br/>
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High Pressure:  Some microbes can survive 130 MPa<br/>
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High Pressure:  Pyrococcus CH1 can survive 120 MPa<br/>
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Vacuum:  Some insects, microbes and seeds can live in total vacuum<br/>
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Vacuum:  Tardigrades can live in a near perfect vacuum<br/>
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Salinity (Concentration):  Dunaliella salina can live in 2-5 M NaCl <br/>
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Salinity (Concentration):  Dunaliella salina can live in 30% NaCl <br/>
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High pH :  As yet unnamed can live in 12.8
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High pH :  Assorted Bacteria can live in 13.2<br/>
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Low pH:  Cyanidium caldarium can survive 0<br/>
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Low pH:  Cyanidium caldarium can survive 0.05<br/>
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Either oxygen deficient OR carbon dioxide deficient environments:  Chloroflexus aurantacus can live in 0M O2 OR 0M CO2<br/>
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Low Water Activity  : Xeromyces bisporus can live in 0.62<br/>
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Low Water Activity  :Saccharomyces rouxii can live in 0.62<br/>
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Longest synthetic genome :Mycoplasma mycoides JCVI-syn1.0 can live in 1.08-mega-base pair<br/>
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<b>Some Extraordinary Synthetic Biology Numbers</b><br/>
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Longest synthetic genome: The 1.08-mega-base pairMycoplasma mycoides JCVI-syn1.0 Genome<br/>
Longest sustained expression of a pore-forming protein in a liposome was 4 Days<br/>
Longest sustained expression of a pore-forming protein in a liposome was 4 Days<br/>
Enzyme efficiency of wintergreen-smell producing Biobrick BBa_J45004 (mM-1⋅s-1) in E. coli is 7.65 ± 0.618<br/>
Enzyme efficiency of wintergreen-smell producing Biobrick BBa_J45004 (mM-1⋅s-1) in E. coli is 7.65 ± 0.618<br/>
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<a href="http://bionumbers.hms.harvard.edu">BioNumbers</a> is the database of useful biological numbers. It aims to
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enable you to find in one minute any common biological number important for your
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research, such as the rate of translation of the ribosome, concentrations of metabolites or
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the number of bacteria in your gut. You will find full references as well as additional extraordinary numbers. Check it out at: www.bioNumbers.hms.harvard.edu.<br/> 
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Please let us know any suggestions and comments: ron.milo@weizmann.ac.il or joseph.steinberger@weizmann.ac.il

Latest revision as of 23:27, 22 December 2011