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| - | {{:Team:DTU-Denmark/Templates/Standard_page_begin|Background: Cis-acting versus trans-acting sRNA }}
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| - | [[File:DTU1_Cis_trans.png|300px|thumb |right|Difference of genomic location for cis- and trans-encoded sRNA. Orange boxes illustrate the sRNA, blue boxes the target mRN, and yellow boxes the ribosome binding site.]]
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| - | Regulatory sRNAs are divided into different sub-groups depending on their genomic locations. '''Cis-encoded''' or '''antisense''' sRNAs are encoded just opposite the one gene they regulate whereas '''trans-encoded''' sRNAs are located somewhere else in the genome and can aim at multiple number of target mRNA. Antisense RNA share extensive sequence complementarity with its target mRNA and hence do not require the RNA chaperone, Hfq, to stabilize the complex. This is in contrast to trans-encoded sRNAs which often only posses a complementary base-pairing region of 6-20 nucleotides and often require Hfq<span class="superscript">[[#References|[1]]]</span>. We are focusing on trans-encoded sRNA in the project, so '''whenever we write sRNA we implicit mean trans-encoded sRNA'''.
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| - | <html></div><div class="whitebox article"></html>
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| - | ==References==
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| - | [1] van Vliet, Arnoud Hm, and Brendan W Wren. “New levels of sophistication in the transcriptional landscape of bacteria.” Genome biology. 10, no. 8 (2009).
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Latest revision as of 18:11, 21 September 2011
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