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Team:Missouri Miners/Project
From 2011.igem.org
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In the bodies of people with type one diabetes, the ability to both recognize and respond to glucose | In the bodies of people with type one diabetes, the ability to both recognize and respond to glucose | ||
| - | concentrations in the blood has been compromised. As a result, glucose accumulates in the blood. High blood | + | concentrations in the blood has been compromised. As a result, glucose accumulates to dangerous levels in the blood. High blood glucose concentrations can cause irreversible damage to several critical organs, impairing the functionality |
| - | glucose concentrations can cause irreversible damage to several critical organs, impairing the functionality | + | |
of those organs. With accessible parts from the iGEM registry we will attempt to integrate a glucose controlled promoter gene linked to a green fluorescence production gene and an insulin production gene. We will then determine | of those organs. With accessible parts from the iGEM registry we will attempt to integrate a glucose controlled promoter gene linked to a green fluorescence production gene and an insulin production gene. We will then determine | ||
the concentrations of glucose to which the promoter responds. Once the concentration is known, we will attempt to | the concentrations of glucose to which the promoter responds. Once the concentration is known, we will attempt to | ||
Revision as of 19:52, 21 July 2011
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Abstract
In the bodies of people with type one diabetes, the ability to both recognize and respond to glucose concentrations in the blood has been compromised. As a result, glucose accumulates to dangerous levels in the blood. High blood glucose concentrations can cause irreversible damage to several critical organs, impairing the functionality of those organs. With accessible parts from the iGEM registry we will attempt to integrate a glucose controlled promoter gene linked to a green fluorescence production gene and an insulin production gene. We will then determine the concentrations of glucose to which the promoter responds. Once the concentration is known, we will attempt to mutate the glucose controlled promoter gene so that it will respond to, and be activated by, concentrations of glucose closer to those of the average human (roughly 5mM).
