Team:UNIST Korea

From 2011.igem.org

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Revision as of 15:42, 14 July 2011

This is a template page. READ THESE INSTRUCTIONS.

You are provided with this team page template with which to start the iGEM season. You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki. You can find some examples HERE.

You MUST have a team description page, a project abstract, a complete project description, a lab notebook, and a safety page. PLEASE keep all of your pages within your teams namespace.

Genetically Modified Organisms (GMOs) pose a significant threat to human health and the environment. Despite being a promising candidate in various processes such as production of drugs and bio-commodities, GMOs do not experience a warm welcome from the human society. Fear of destruction of the natural biota suppresses all of the benefits offered by GMOs. Horizontal gene transfer (HGT) from GMOs to some pathogenic microbes, which leads to superbugs, is yet another major concern with GMOs. Here, we design a GMO with a built-in triggered-suicide system that is inducible by environmental signals (such as light, oxygen, heavy metals or quorum sensing system). This selfless GMO would kill itself on receiving environmental cues when it is released from its native completely closed system (fermentor or laboratory) to the open system (surrounding environment). We propose the use of a novel suicide platform using the genes coding for the restriction enzyme, DpnI that would chew up all methylated DNAs. This novel suicide platform may help prevent HGT and in turn enhance the potential benefits offered by GMOs. .
Tell us more about your project. Give us background. Use this as the abstract of your project. Be descriptive but concise (1-2 paragraphs)	File:UNIST Korea team.png Your team picture
	Team Example

Home	Team	Official Team Profile	Project	Parts Submitted to the Registry	Modeling	Notebook	Safety	Attributions

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-|You can write a background of your team here.  Give us a background of your team, the members, etc.  Or tell us more about something of your choosing.
+|Genetically Modified Organisms (GMOs) pose a significant threat to human health and the environment. Despite being a promising candidate in various processes such as production of drugs and bio-commodities, GMOs do not experience a warm welcome from the human society. Fear of destruction of the natural biota suppresses all of the benefits offered by GMOs. Horizontal gene transfer (HGT) from GMOs to some pathogenic microbes, which leads to superbugs, is yet another major concern with GMOs. Here, we design a GMO with a built-in triggered-suicide system that is inducible by environmental signals (such as light, oxygen, heavy metals or quorum sensing system). This selfless GMO would kill itself on receiving environmental cues when it is released from its native completely closed system (fermentor or laboratory) to the open system (surrounding environment). We propose the use of a novel suicide platform using the genes coding for the restriction enzyme, DpnI that would chew up all methylated DNAs. This novel suicide platform may help prevent HGT and in turn enhance the potential benefits offered by GMOs. .
 |[[Image:UNIST_Korea_logo.png|200px|right|frame]]
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