Team:UST-Beijing

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    <td colspan="3" rowspan="2"><img src="https://static.igem.org/mediawiki/2011/6/6e/Ustblogo.jpg" alt="Header image" width="715" height="178" border="0" /></td>
 
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    <td height="75" colspan="2" align="center" valign="bottom" bgcolor="#33FF00" id="logo"><h4 align="left"><img src="https://static.igem.org/mediawiki/2011/f/f0/IGEM_logo.png" width="119" height="91" align="bottom" /><span class="STYLE7">2011</span></h4></td>
 
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    <th height="54" colspan="2" align="center" valign="middle" bordercolor="#ECE9D8" id="tagline"><h1 align="center" class="pageName STYLE4">UST-Beijing</h1></th>
 
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<img src="https://static.igem.org/mediawiki/2011/6/6e/Ustblogo.jpg" width="602" height="294" />
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<img src="https://static.igem.org/mediawiki/2011/3/30/USTB3.jpg" width="351" height="341" />
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     <td width="109"><div align="center"><u><strong><em><a href="https://2011.igem.org/Team:UST-Beijing/Team">TEAM团队</a></em></strong></u></div></td>
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    <td width="156"><div align="center"><u><strong><em><a href="https://2011.igem.org/Team:UST-Beijing/Project">PROJECT项目</a></em></strong></u></div></td>
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    <td width="148"><div align="center"><u><strong><em><a href="https://2011.igem.org/Team:UST-Beijing/Notebook">NOTES笔记</a></em></strong></u></div></td>
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     <td width="169"><div align="center"><u><strong><em><a href="https://2011.igem.org/Team:UST-Beijing/Parts">PARTS零件</a></em></strong></u></div></td>
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     <td width="181"><div align="center"><u><strong><em><a href="https://2011.igem.org/Team:UST-Beijing/safety">SAFETY安全</a></em></strong></u></div></td>
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     <td width="168"><div align="center"><u><strong><em><a href="https://2011.igem.org/Team:UST-Beijing/Attributions">ATTRIBUTHANKS感谢</a></em></strong></u></div></td>
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          <td height="33"><a href=https://2011.igem.org/Team:UST-Beijing class="navText">Home</a></td>
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          <td width="165"><a href=https://2011.igem.org/Team:UST-Beijing/Team class="navText">Team</a></td>
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          <td width="165"><a href=https://igem.org/Team.cgi class="navText">Official Team Profile</a></td>
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          <td width="165"><a href=https://2011.igem.org/Team:UST-Beijing/Project class="navText">Project</a></td>
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          <td width="165"><a href=https://2011.igem.org/Team:UST-Beijing/Parts Submitted to the Registry class="navText">Parts Submitted to the Registry </a></td>
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          <td><a href=https://2011.igem.org/Team:UST-Beijing/Modeling class="navText">Modeling</a></td>
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          <td><a href=https://2011.igem.org/Team:UST-Beijing/Notebook class="navText">Notebook</a></td>
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          <td><a href="javascript:;" class="navText">Acknowledgement</a></td>
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          <td width="165"><a href=https://2011.igem.org/Team:UST-Beijing/Attributions class="navText">Attributions</a></td>
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          <td width="505" height="26" class="pageName">Welcome to UST-Beijing </td>
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          <td height="487" class="bodyText"><p><img src="https://static.igem.org/mediawiki/2011/2/20/%E5%8C%97%E4%BA%AC%E7%A7%91%E6%8A%80%E5%A4%A7%E5%AD%A6.jpg" width="481" height="381" align="texttop" /></p>
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          <p align="left" class="navText STYLE8"> The University of Science and Technology Beijing (USTB) was founded in 1952  following the amalgamation of the best departments in related fields of five  eminent universities as a result of a nationwide reorganization of the higher  education system. USTB values greatly and will for ever cherish its long tradition of being  &quot;Rigorous in Learning and Research and Venerating Practice&quot;. USTB is now working hard towards its goal of becoming one of the top-ranking  research universities in China and an internationally renowned higher education  institute with its own distinguishing features.</p>
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          <p>&nbsp;</p></td>
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    <td width="203" valign="top"><p><span class="smallText"><img src="https://static.igem.org/mediawiki/2011/e/ef/%E9%93%B6%E6%9D%8F.JPG" alt="Image 1" width="184" height="117" vspace="6" border="0" align="texttop" /></span><span class="smallText"><span class="subHeader"> Visual of our campus</span><br />
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      <a href="javascript:;">Read more &gt;</a></span><img src="https://static.igem.org/mediawiki/2011/e/ed/Team_wiki.jpg" alt="Image 2" width="182" height="141" vspace="6" border="0" /></p>
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    <p>Back to the Team Wikis <br />
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      <a href="javascript:;">Click Here &gt;</a><img src="https://static.igem.org/mediawiki/2011/6/61/Main_Page.png" width="183" height="117" /></p>
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    <p>Back to the Main_Page </p>
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    <p><a href="javascript:;">Click Here &gt;</a></p></td>
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    <td width="8">&nbsp;</td>
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    <td width="177" valign="top"><h2><strong>Instructors</strong></h2>
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    <p><img src="https://static.igem.org/mediawiki/2011/3/35/Songqing.jpg" width="120" height="160" /></p>
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    <p class="STYLE13">Prof.Ching Song</p>
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    <p class="STYLE13">Doc. Huai Zhang </p></td>
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    <td width="476"><h2 class="STYLE9">PROJECT</h2>
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    <p class="STYLE10"> Gene H-transfer: bile acid receptor in E.coli & proteorhodpsin in mitochindrial inner membrane
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.  In order to celebrate the power of gene H(orizontal)-transfer between pro- and eukaryotes, we constructed two fusion proteins and tested their function: (1). a synthetic bile acid receptor in E.coli using a mammalian nuclear receptor LXR. As proof-of-principle, the regulatory circuit in symbiotic bacteria could be harmoniously linked to metabolic pathway of their host.  Potential application includes in situ synthesis of pharmaceuticals on-demand in the digestive tract.  (2) a synthetic light-driven proton pump in human mitocondrial inner membrane using a bacterial proteorhodopsin. Preliminary testing demonstrated cellular sensitivity to light radiation.  Application and utility relies on result of in-depth characterization of such system design.  For (1).We are using lacI DNA-binding domain and LXRbeta ligand-binding domain, we made  an artificial bile acid receptor which can regulate expression of target gene  within a natural lacI operon. As proof of principle, we demonstrate that  regulation of bacteria gene expression by host eukaryocyte metabolites is  achievable using chimeric nuclear receptors. Through directed molecular  evolution, a harmonious signal network regulating metabolism of both  prokaryocytes and their host eukaryocytes in the digestive tract is feasible. </p>
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    <p class="STYLE10"><img src="https://static.igem.org/mediawiki/2011/5/5a/LacI_rUR.png" width="233" height="222" /><img src="https://static.igem.org/mediawiki/2011/5/5a/Bile_%EF%BC%A1%EF%BD%83%EF%BD%89%EF%BD%84.jpg.jpg" width="233" height="222" /></p>
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    <p>&nbsp;</p>
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    <p>&nbsp;</p>    </td>
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    <td width="7" rowspan="3" valign="top"><h2>&nbsp;</h2>
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    <p>&nbsp;</p></td>
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    <td width="203" rowspan="2" valign="top"><h2>Parts Submitted to the Registry </h2>
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    <td width="177" valign="top"><span class="STYLE11">Acknowledgement</span></td>
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    <td><h2>TEAM</h2>
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      <p><img src="https://static.igem.org/mediawiki/2011/b/b1/Team.JPG" width="471" height="378" /></p>
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      <p class="smallText"><span class="STYLE10">These are our team members for the 2011 iGEM, Do you want to know more about us ?</span> <a href="javascript:;" class="quote STYLE12">;<a href=https://2011.igem.org/Team:UST-Beijing/Team class="navText">click here</a></td>
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</a></p>
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    <p>&nbsp;</p></td>
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    <p><img src="BIO-RAD.jpg" width="110" height="33" /></p></td>
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    <td><h2>Safety</h2>
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      <p class="STYLE11">We had a serious discussion before and we asked ourselves the following four questions. And of course, We got the answers. </p>
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      <p><span class="STYLE11"><strong>1.Would any of your project ideas raise safety issues in terms of: researcher  safety, public safety, or environmental safety?</strong> Since modern time molecular  biology and gene engineering is a &quot;reverse engineering&quot; process, which means  that we discover and acquire research tools from the existing genes and  structures, our iGEM projects in theory might influence natural and existing  biological structures and functions in our laboratory.However, any reagents made in our lab is not infectious or contiguous; even in  the case of being released by accident, will not impose safety threats to our  lab members, people around us, general public, or environment in general. Early  pioneers of molecular biology developed a self-disciplined code of ethics to  prevent intentional usage of biological reagents, and engineered a stack of  laboratory-dependent species for research-only use to prevent unintentional  release and contamination of the environment. We plan to inherit the high  standard ethical code of action and common molecular biology reagents to meet  the requirement for human and environmental safety. In addition, we will  introduce biosafety issues and guide-lines to the undergraduate students of life  science major as an inseparable part of the academic curriculum to advocate  biosafety awareness and promote biosafety education. </span><a href="javascript:;" class="STYLE11"><a href=https://2011.igem.org/Team:UST-Beijing/safety class="navText">Read more</a></td>
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    <td width="203" valign="top"><h2>Notebook</h2></td>
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<p><img src="https://static.igem.org/mediawiki/2011/5/5a/Bile_%EF%BC%A1%EF%BD%83%EF%BD%89%EF%BD%84.jpg" width="172" height="78" /><a href="https://static.igem.org/mediawiki/2011/6/6b/1.swf"><img src="https://static.igem.org/mediawiki/2011/9/9e/1~2.gif" width="190" height="127"></a><a href="https://static.igem.org/mediawiki/2011/c/c7/2.swf"><img src="https://static.igem.org/mediawiki/2011/5/56/2~2.gif" width="180" height="127"></a><a href="https://static.igem.org/mediawiki/2011/9/97/3.swf"><img src="https://static.igem.org/mediawiki/2011/5/5c/3~1.gif" width="171" height="127"></a><a href="https://static.igem.org/mediawiki/igem.org/c/c0/Model.mov"><img src="https://static.igem.org/mediawiki/2011/8/87/Lightpump.JPG" width="235" height="92" /></a></p>
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