Team:Wisconsin-Madison/bmc

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Revision as of 22:37, 28 September 2011

Project >> Overview, Ethanol Sensor, Alkane Sensor, Microcompartment

Bacterial Microcompartment (BMC)

Bacterial microcompartments are tiny protein-assembled compartments which have been newly discovered in many bacteria strains. Their existence in cells enables bacteria to compact certain reactions within small defined space such that the enzyme efficiency can be increased due to folded substrate concentration. Also, generated mediates from toxic reactions can be separated from the rest of cell contents. The Pdu microcompartment, which was originally found in Salmonella enterica and Citrobactor freundii, encloses metabolisms that utilize propanediol as a carbon source. Literature and former USTC iGEM 2010 team showed that empty microcompartments can be successfully assembled in E. coli and certain genes are thought to be able to direct proteins to the outer or inner surfaces of the microcompartments. Based on these findings, the UW-Madison 2011 iGEM team believe that BMC has the potential to dramatically improve bacteria production and sensing efficiency and can be further remodeled to conduct new functions. So far we are trying to assemble pdu microcompartments in E.coli, characterize their assembly rates, and make E.coli produce biofuels and their fatty acid precursors.

Learn more about biofuels.

Image Source: http://people.mbi.ucla.edu/mbiasst/Test/MemberResearchImages/Images/Yeates2.jpg

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-Bacterial Microcompartment
+Bacterial Microcompartment (BMC)
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-Bacterial microcompartments (BMC) are tiny protein-assembled compartments which are newly discovered in many bacteria strains. Their existence in cells enables bacteria to compact certain reactions within small defined space such that the enzyme efficiency can be increased due to folded substrate concentration and also those generated mediates from toxic reactions are separated from the rest of cell contains. Pdu microcompartment, which was originally found in Salmonella enteric and Citrobactor freundii, encloses metabolisms that utilize propanediol as a carbon resource. Literatures and former USTC iGEM 2010 team showed that empty microcompartments can be successfully assembled in E. coli and some genes are suggested to be able to direct proteins to outer surface or inner parts of the microcompartments respectively. Based on these findings, we UW-Madison 2011 iGEM team believe that BMC has the potentiality to dramatically improve bacteria production efficiency and can be further remodeled to conduct new functions. And so far, we are trying to assemble pdu microcompartments in E.coli, characterize the assembly rates and make E.coli produce biofuels such as butanol and fatty acids.
+Bacterial microcompartments are tiny protein-assembled compartments which have been newly discovered in many bacteria strains. Their existence in cells enables bacteria to compact certain reactions within small defined space such that the enzyme efficiency can be increased due to folded substrate concentration. Also, generated mediates from toxic reactions can be separated from the rest of cell contents. The Pdu microcompartment, which was originally found in Salmonella enterica and Citrobactor freundii, encloses metabolisms that utilize propanediol as a carbon source. Literature and former <a href="https://2010.igem.org/Team:USTC">USTC iGEM 2010</a> team showed that empty microcompartments can be successfully assembled in E. coli and certain genes are thought to be able to direct proteins to the outer or inner surfaces of the microcompartments. Based on these findings, the UW-Madison 2011 iGEM team believe that BMC has the potential to dramatically improve bacteria production and sensing efficiency and can be further remodeled to conduct new functions. So far we are trying to assemble pdu microcompartments in E.coli, characterize their assembly rates, and make E.coli produce biofuels and their fatty acid precursors.
 <p><br>
 Learn more about <a href="https://2011.igem.org/Team:Wisconsin-Madison/biofuels">biofuels</a>.
 <p>
-<font size="1"><i>Image Source: sddddddddddddddddddddddddddddddddddd</i></font>
+<font size="1"><i>Image Source: http://people.mbi.ucla.edu/mbiasst/Test/MemberResearchImages/Images/Yeates2.jpg</i></font>