Team:Wageningen UR/Safety/Eight

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Latest revision as of 21:05, 21 September 2011

Building a Synchronized Oscillatory System

Biosafety and biosecurity considerations

Does your country have national biosafety regulations or guidelines?

In the Netherlands, any person or institution intending to perform genetic modifications is required to obtain licenses under the Royal Order on Genetic Modified Organisms (which is called ‘Besluit GGO’ in Dutch), Regulation Genetic Modified Organisms (‘Regeling GGO’) and environmental legislation as the Law on Environmental Management (‘Wet Milieubeheer’). The Dutch governmental page on [http://www.rijksoverheid.nl/onderwerpen/biotechnologie/wetten-en-regels-biotechnologie Biotechnology laws] directs to these laws. Food related genetic modifications and border crossing transport of genetically modified (micro-)organisms are also regulated by European legislation. While neither one of these is valid for our project this will not be expanded upon further on this page, but more information could be found on the site of the European [http://bch.cbd.int/ Biosafety Clearing-House].

The Royal Order on Genetic Modified Organisms is for the greater part about the classification of the organisms, in which consideration is taken regarding possible modifications of their genomes. Our team has applied this information by rejecting any project idea that required a cell chassis of BSL 2 and higher from the list with brainstorm ideas we made.

According to the Regulation Genetic Modified Organisms, Wageningen UR employs a number of (biological) safety workers. Every lab has one or more laboratory manager(s). The laboratory manager sees to it that genetic modification related research is being executed according to the involved rules. If an accident happens, like aerosol formation, the manager also is the first person who would be notified about this. Because they create safer lab work conditions, the practical tutor’s instruction, supervision and presence are very welcome.

The Law on Environmental Management notes especially the actions that should be taken into account in case the environment gets into contact with genetically modified organisms. These actions are stated generally. If this occasion would appear, we are responsible to do everything in our ability to solve the problem. This means we should inform the Biosafety officer, which then will inform the license holder, that again informs our Minister and environmental agencies for thoroughly sterilization. To provide directly available information to the Minister, furthermore, there’s a document with information about the micro-organism that is used and a safety assessment of the project.

Although our team did not choose to design constructs in order to help and to be present in the environment, we would like to notify that such a genetic modified organism might be approved under European legislation. The presence of a genetically modified organism in the environment can be allowed under several conditions. The Eur-Lex Home states that an environmental impact assessment would have to be made and safety and emergency measures have to be documented well (2001). Eur-Lex Home moreover indicates that an accredited Dutch institution would have to approve the introduction (2001). Finally, Eur-Lex Home stresses that each case would have to be treated separately (2001). Thus, introducing a potentially beneficial BioBrick system or device to the environment is not restricted by all means, but it requires a lot of paperwork to get approval.

Finally, when microorganisms (or plants) are genetically modified ethics and societal issues are not looked at by the Dutch government. Therefore only the above mentioned regulations have to be applied in the Netherlands.

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-<!-- safety page 4 -->
+<!-- safety page 8 -->
-== Safety ==
+<html>
+<head>
+<style type="text/css">
+ul li a.currentlinktop7 {
+color: #63a015 !important;
+} <!-- why is the safety button still not green? -->
+ul li a.currentlinksafety9 {
+color: black !important;
+}
+ul li a.currentlinksafety10 {
+color: black !important;
+}
+ul li a.currentlinksafety9 {
+color: black !important;
+}
+</style>
+</head>
+<bod>
+</body>
+</html>
+{{:Team:Wageningen_UR/Templates/Header}}
+{{:Team:Wageningen_UR/Templates/NavigationTop1}}
+== Biosafety and biosecurity considerations ==
+{{:Team:Wageningen_UR/Templates/NavigationLeft4}}
 {{:Team:Wageningen_UR/Templates/Style | text= __NOTOC__
-=== Improvements on safety ===
+=== Does your country have national biosafety regulations or guidelines? ===
+In the Netherlands, any person or institution intending to perform genetic modifications is required to obtain licenses under the Royal Order on Genetic Modified Organisms (which is called ‘Besluit GGO’ in Dutch), Regulation Genetic Modified Organisms (‘Regeling GGO’) and environmental legislation as the Law on Environmental Management (‘Wet Milieubeheer’). The Dutch governmental page on [http://www.rijksoverheid.nl/onderwerpen/biotechnologie/wetten-en-regels-biotechnologie Biotechnology laws] directs to these laws. Food related genetic modifications and border crossing transport of genetically modified (micro-)organisms are also regulated by European legislation. While neither one of these is valid for our project this will not be expanded upon further on this page, but more information could be found on the site of the European [http://bch.cbd.int/ Biosafety Clearing-House].
+The Royal Order on Genetic Modified Organisms is for the greater part about the classification of the organisms, in which consideration is taken regarding possible modifications of their genomes. Our team has applied this information by rejecting any project idea that required a cell chassis of BSL 2 and higher from the list with brainstorm ideas we made.
-===== Embracing the public =====
+According to the Regulation Genetic Modified Organisms, Wageningen UR employs a number of (biological) safety workers. Every lab has one or more laboratory manager(s). The laboratory manager sees to it that genetic modification related research is being executed according to the involved rules. If an accident happens, like aerosol formation, the manager also is the first person who would be notified about this. Because they create safer lab work conditions, the practical tutor’s instruction, supervision and presence are very welcome.
-Understanding should come with knowledge. It might be beneficial for the development of Synthetic Biology and the society if the public will be allowed to follow projects on close watch. Probably even more if this is as close as joining a day in the lab, well maybe by viewing it via a video monitoring. In this way the biosafety regarding human health and the spread of disease won’t be at stake and might still be as fun to do. Our team has set this up and it can be found on the Social Media page. In combination with the, freely available, Wiki information pages of iGEM it could be possible for the public to test if any concerns about ‘Synthetic Biology’ were right or exaggerated. In order to provide the possibility of noting any – in this case: nuanced – concerns people should be able to add these on a Wiki page especially arranged for it. This page should give a clear overview of comments about projects. Synthetic biologists could give answers to questions on this site. This direct possibility of interaction should reduce the feeling of missing hold on Synthetic Biology and, with it, fear about it.
+The Law on Environmental Management notes especially the actions that should be taken into account in case the environment gets into contact with genetically modified organisms. These actions are stated generally. If this occasion would appear, we are responsible to do everything in our ability to solve the problem. This means we should inform the Biosafety officer, which then will inform the license holder, that again informs our Minister and environmental agencies for thoroughly sterilization. To provide directly available information to the Minister, furthermore, there’s a document with information about the micro-organism that is used and a safety assessment of the project.
-With outreach our team furthermore tried to contribute to make the public more aware of the actual content of iGEM and partly Synthetic Biology.
+Although our team did not choose to design constructs in order to help and to be present in the environment, we would like to notify that such a genetic modified organism might be approved under European legislation. The presence of a genetically modified organism in the environment can be allowed under several conditions. The Eur-Lex Home states that an environmental impact assessment would have to be made and safety and emergency measures have to be documented well (2001). Eur-Lex Home moreover indicates that an accredited Dutch institution would have to approve the introduction (2001). Finally, Eur-Lex Home stresses that each case would have to be treated separately (2001). Thus, introducing a potentially beneficial BioBrick system or device to the environment is not restricted by all means, but it requires a lot of paperwork to get approval.
-With understanding comes involvement, this might give rise to a growing improvement on iGEM and Synthetic Biology in general.
+Finally, when microorganisms (or plants) are genetically modified ethics and societal issues are not looked at by the Dutch government. Therefore only the above mentioned regulations have to be applied in the Netherlands.
 }}