Team:Wageningen UR/Project/ModelingProj1
From 2011.igem.org
(→Modeling synchronized oscillations) |
(→Modeling synchronized oscillations) |
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=== Short repetition of the Hasty construct used as base for our system === | === Short repetition of the Hasty construct used as base for our system === | ||
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+ | For a better understanding of the equations shown below, Figure 1 shows a short repetition of the circuit we used as a base for our design, in our team commonly referred to as the "Hasty construct". | ||
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'''Fig.1:''' ''Basic oscillating genetic circuit as published by Danino & Hasty.'' | '''Fig.1:''' ''Basic oscillating genetic circuit as published by Danino & Hasty.'' | ||
- | + | The genes luxI and aiiA can be expressed when a AHL-LuxR complex binds to the promoter region. The circuit uses both a positive and negative feedback loop to control the AHL concentration and therefore the expression of the resulting proteins LuxI and AiiA. In the positive loop, LuxI genererates more AHL, which in turn stimulates t | |
=== Mathematical model of the construct === | === Mathematical model of the construct === |
Revision as of 21:32, 11 September 2011