Team:WHU-China/Project/Modeling
From 2011.igem.org
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- | The system including two protein: | + | The system including two protein:</br> |
- | Using differential equation to describe the system: | + | Using differential equation to describe the system:</br> |
- | Where means the volume of , means the volume of , means the delay time of the reaction. | + | Where means the volume of , means the volume of , means the delay time of the reaction. |
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- | where: means the volume of | + | where: means the volume of </br> |
- | though dimensionless: | + | though dimensionless:</br> |
- | The balance point of the equation is and | + | The balance point of the equation is and |
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- | is the Hopf bifurcation point , when ,it is able to generate a stable periodic solution. | + | is the Hopf bifurcation point , when ,it is able to generate a stable periodic solution. |
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- | is the Hopf bifurcation point , when ,it is able to generate a stable periodic solution. | + | is the Hopf bifurcation point , when ,it is able to generate a stable periodic solution. |
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- | is the Hopf bifurcation point , when ,it is able to generate a stable periodic solution. | + | is the Hopf bifurcation point , when ,it is able to generate a stable periodic solution. |
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- | is the Hopf bifurcation point , when ,it is able to generate a stable periodic solution. | + | is the Hopf bifurcation point , when ,it is able to generate a stable periodic solution. |
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<p>As the changes of cycle time with the change of the parameters in the image , we can get the conclusion that:</br> | <p>As the changes of cycle time with the change of the parameters in the image , we can get the conclusion that:</br> | ||
- | 1. have little influence on the range.</br> | + | 1. have little influence on the range.</br> |
- | 2. do not have much influence on the cycle time.</br> | + | 2. do not have much influence on the cycle time.</br> |
- | 3. have inversely proportional relationship with the cycle time , it have a huge influence on the cycle time , but little impact on the range (Can be used to adjust the cycle to maintain constant amplitude)</br> | + | 3. have inversely proportional relationship with the cycle time , it have a huge influence on the cycle time , but little impact on the range (Can be used to adjust the cycle to maintain constant amplitude)</br> |
- | 4. When , have little influence on the range. | + | 4. When , have little influence on the range. |
</br> | </br> | ||
This conclusion we get before can be used to guide the design of biological systems, in order to achieve the adjustment period, amplitude can adjust the size of some parameters.</p> | This conclusion we get before can be used to guide the design of biological systems, in order to achieve the adjustment period, amplitude can adjust the size of some parameters.</p> |
Revision as of 06:44, 1 October 2011
Using the MATLAB software to plot we got the solution image:
Cycle with the curve of each parameter:
As the changes of cycle time with the change of the parameters in the image , we can get the conclusion that: 1. have little influence on the range. 2. do not have much influence on the cycle time. 3. have inversely proportional relationship with the cycle time , it have a huge influence on the cycle time , but little impact on the range (Can be used to adjust the cycle to maintain constant amplitude) 4. When , have little influence on the range. This conclusion we get before can be used to guide the design of biological systems, in order to achieve the adjustment period, amplitude can adjust the size of some parameters.