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Team:Virginia
From 2011.igem.org
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Hi! We're the iGEM team at the University of Virginia. A Synthetic Biology Approach to Promoting Angionesis at Traumatic Wound Sites We use a synthetic biology approach to promote tissue regeneration at traumatic wound sites. Tissue regeneration is composed of three primary processes: the regrowth of functional parenchymal tissue, the regrowth of support tissues, and the regrowth of vasculature to sustain the nascent tissue formation (angiogenesis). Although tissue engineering has offered several effective solutions to address the first two processes, our project attempts to build upon these ideas and develop a more cost-effective and robust method to promote angiogenesis at traumatic wound sites. We have devised a circuit to be incorporated in a yeast chassis that efficiently expresses two vital angiogenic proteins--vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF-B)--in a sequential and time-dependent manner that approximates the natural cascade of growth factor release in the human body. We also intend to submit a Biobrick-compatible yeast plasmid backbone for future use. |
