Team:Virginia

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'''WEBSITE UNDER CONSTRUCTION--CHECK BACK AFTER SEPTEMBER 28TH'''
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Hi! We're the iGEM team at the University of Virginia.
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'''A Synthetic Biology Approach to Promoting Angionesis at Traumatic Wound Sites'''
 
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We use a synthetic biology approach to promote tissue regeneration at traumatic wound sites. Tissue regeneration is composed of three primary processes: the regrowth of functional parenchymal tissue, the regrowth of support tissues, and the regrowth of vasculature to sustain the nascent tissue formation (angiogenesis).
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Although tissue engineering has offered several effective solutions to address the first two processes, our project attempts to build upon these ideas and develop a more cost-effective and robust method to promote angiogenesis at traumatic wound sites. We have devised a circuit to be incorporated in a yeast chassis that efficiently expresses two vital angiogenic proteins--vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF-B)--in a sequential and time-dependent manner that approximates the natural cascade of growth factor release in the human body. We also intend to submit a Biobrick-compatible yeast plasmid backbone for future use.
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<div class="bannersubnav"><a href="#" >Privacy Policy</a> | <a href="#" >Contact Us</a> | <a href="#" >Site Map</a></div>
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<li><a href="#" >PROJECT</a></li>
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                    <li><a href="#" >PARTS</a></li>
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                    <li><a href="#" >MODELING</a></li>
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                    <li><a href="#" >NOTEBOOK</a></li>
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                    <li><a href="#" >SAFETY</a></li>
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                    <li><a href="#" >HUMAN PRACTICES</a></li>
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                    <li><a href="#" >RESOURCES</a></li>
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                    <li><a href="#" >TEAM</a></li>
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                    <li><a href="#" >CONTACT</a></li>
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[WEBSITE UNDER CONSTRUCTION]
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<div class="AccordionPanelTab">Our Project</div>
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<h2>A synthetic biology approach to promoting angiogenesis at traumatic wound sites</h2>
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<p>We use a synthetic biology approach to promote tissue regeneration at traumatic wound sites. Tissue regeneration is composed of three primary processes: the regrowth of functional parenchymal tissue, the regrowth of support tissues, and the regrowth of vasculature to sustain the nascent tissue formation (angiogenesis).</p>
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                                <p>
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Although tissue engineering has offered several effective solutions to address the first two processes, our project attempts to build upon these ideas and develop a more cost-effective and robust method to promote angiogenesis at traumatic wound sites. We have devised a circuit to be incorporated in a yeast chassis that efficiently expresses two vital angiogenic proteins--vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF-B)--in a sequential and time-dependent manner that approximates the natural cascade of growth factor release in the human body. We also intend to submit a Biobrick-compatible yeast plasmid backbone for future use.</p>
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<div class="AccordionPanelTab">About Us</div>
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<p>The Virginia team has been competing at iGEM competitions since 2007. Our current team is made up of 5 undergraduate students interested in fields ranging from biomedical research to law and economics to chemical engineering to psychology.</p>
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<div class="AccordionPanelTab">Resources</div>
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<p>We've developed a set of easy-to-use tools to aid in manipulating sequences to meet the requirements of various assembly methods. We've also published a human practices paper that introduces intellectual property as it relates to synthetic biology and presents alternative methods of driving innovation.</p>
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  <h1>Our sponsors</h1>
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<p>We'd like to thank the College of Arts and Sciences, the School of Engineering and Applied Science, the Alumni Lacy Fund, and the Office of the Vice President for Research for providing funding for this project.</p>
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<h1>About Us</h1>
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<p>We're a group of five undergraduates at the University of Virginia from the departments of Chemical Engineering, Biomedical Engineering, and Psychology. Our research was overseen by three faculty advisors: Professor Kozminski, Professor Kwon, and Professor Papin.</p>
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Revision as of 14:50, 24 September 2011

Team Virginia

Privacy Policy | Contact Us | Site Map
[WEBSITE UNDER CONSTRUCTION]
Our Project

A synthetic biology approach to promoting angiogenesis at traumatic wound sites

We use a synthetic biology approach to promote tissue regeneration at traumatic wound sites. Tissue regeneration is composed of three primary processes: the regrowth of functional parenchymal tissue, the regrowth of support tissues, and the regrowth of vasculature to sustain the nascent tissue formation (angiogenesis).

Although tissue engineering has offered several effective solutions to address the first two processes, our project attempts to build upon these ideas and develop a more cost-effective and robust method to promote angiogenesis at traumatic wound sites. We have devised a circuit to be incorporated in a yeast chassis that efficiently expresses two vital angiogenic proteins--vascular endothelial growth factor (VEGF) and platelet derived growth factor (PDGF-B)--in a sequential and time-dependent manner that approximates the natural cascade of growth factor release in the human body. We also intend to submit a Biobrick-compatible yeast plasmid backbone for future use.

About Us

The Virginia team has been competing at iGEM competitions since 2007. Our current team is made up of 5 undergraduate students interested in fields ranging from biomedical research to law and economics to chemical engineering to psychology.

Resources

We've developed a set of easy-to-use tools to aid in manipulating sequences to meet the requirements of various assembly methods. We've also published a human practices paper that introduces intellectual property as it relates to synthetic biology and presents alternative methods of driving innovation.

Our sponsors

We'd like to thank the College of Arts and Sciences, the School of Engineering and Applied Science, the Alumni Lacy Fund, and the Office of the Vice President for Research for providing funding for this project.

About Us

We're a group of five undergraduates at the University of Virginia from the departments of Chemical Engineering, Biomedical Engineering, and Psychology. Our research was overseen by three faculty advisors: Professor Kozminski, Professor Kwon, and Professor Papin.

Copyleft. All rights reversed.

Retrieved from "http://2011.igem.org/Team:Virginia"