SJTU-BioX-Shanghai iGEM team is designing a set of Codon-Switches that regulate target protein biosynthesis (translation).
Besides, our device can be made into switches that can be turned on/off without background noise in two ways. One is to use stop codon as the controlling element, the Stop-Codon Switch. The other is to use any codon but the original start codon to initiate translation, the Initial-Codon Switch.
Our design has expanded the regulating tools for synthetic biology and introduced brand-new methods for protein function analysis. See more about project applications, click here.
Built our Rare-Codon Switch in silic and demonstrated the reliability of the model through our experiment results.
Demonstrated device application by constructing and successfully testing positive feedback with our device in metabolic pathway.
Constructed 27 biobricks in our 3 sub-projects.
Analysed the structures of 18 aaRS with structural biological methods. Designed structures of 14 modified aaRS deprived of their anticodon recognition ability.
Expanded the regulating tools for synthetic biology and developed two brand-new ways that facilitate the study of protein function.
Designed our Human Practice Project: T-PostCards to promote our views on synthetic biology through communications and connections.
Promoted synthetic biology in high school class. Designed a questionnaire and did a survey on high school students' understandings and attitudes towards synthetic biology.
Attended the 2011 China Meet Up and presented our project idea to other iGEMer and advisors.