From 2011.igem.org
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| - | <!-- *** What falls between these lines is the Alert Box! You can remove it from your pages once you have read and understood the alert *** -->
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| - | <div id="template" style="text-align: center; font-weight: bold; font-size: large; color: #f6f6f6; padding: 5px;">
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| - | This is a template page. READ THESE INSTRUCTIONS.
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| - | You are provided with this team page template with which to start the iGEM season. You may choose to personalize it to fit your team but keep the same "look." Or you may choose to take your team wiki to a different level and design your own wiki. You can find some examples <a href="https://2008.igem.org/Help:Template/Examples">HERE</a>.
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| - | You <strong>MUST</strong> have a team description page, a project abstract, a complete project description, a lab notebook, and a safety page. PLEASE keep all of your pages within your teams namespace.
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| - | |You can write a background of your team here. Give us a background of your team, the members, etc. Or tell us more about something of your choosing.
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| - | |[[Image:Osaka_logo.png|200px|right|frame]]
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| - | ''Tell us more about your project. Give us background. Use this is the abstract of your project. Be descriptive but concise (1-2 paragraphs)''
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| - | |[[Image:Osaka_team.png|right|frame|Your team picture]]
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| - | |align="center"|[[Team:Osaka | Team Example]]
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| - | !align="center"|[[Team:Osaka|Home]]
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| - | !align="center"|[[Team:Osaka/Team|Team]]
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| - | !align="center"|[https://igem.org/Team.cgi?year=2010&team_name=Osaka Official Team Profile]
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| - | !align="center"|[[Team:Osaka/Project|Project]]
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| - | !align="center"|[[Team:Osaka/Parts|Parts Submitted to the Registry]]
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| - | !align="center"|[[Team:Osaka/Modeling|Modeling]]
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| - | !align="center"|[[Team:Osaka/Notebook|Notebook]]
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| - | !align="center"|[[Team:Osaka/Safety|Safety]]
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| - | !align="center"|[[Team:Osaka/Attributions|Attributions]]
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| | == '''Overall project''' == | | == '''Overall project''' == |
Revision as of 15:43, 2 September 2011
Overall project
In the modern world, radioactivity is a phenomena well understood by science, and harnessed by engineering for nuclear power generation, radiology in medicine, radioisotopic labeling in biological studies and numerous other applications. However, it is an undeniable fact that the ionizing radiation resulting from radioactive decay may cause critical effects on biological creatures, from the smallest bacteria to plants and animals including humans.
On March 11, 2011, the Great East Japan Earthquake struck off the coast of Eastern Japan and triggered a series of equipment failures, nuclear meltdowns, and releases of radioactive materials at the Fukushima 1 Nuclear Power Plant, leading to a nationwide nuclear crisis. While ‘Grays’, ‘Sieverts’, ‘exposure’, ‘equivalent dosage’ and other related terms and units became referred daily in the media, much of the general populace remained ignorant of their meanings and significance. The need for low-cost, portable and easy-to-use dosimeters was apparent as measurements of radiation exposure could only be conducted at dedicated installations spaced far apart and the numbers reported only infrequently.
Hence, this year, iGEM Osaka has decided to tackle the subject of building a biological dosimeter. Focus will be placed on modularly transferring radiation-response and DNA repair genes from the extremophilic bacterium Deinococcus radiodurans to the well-characterized, easily cultivable chassis of Escherichia coli. Once radioresistance has been conferred, the native DNA damage detection and repair systems of E. coli will be tweaked to enable efficient sensing of ionizing radiation through detection of the resultant DNA damage. Finally, the system will be connected to well-defined, visible outputs such as color pigment production through further introduction of heterologous genes, resulting in a biological device capable of detecting ionizing radiation and alerting users to it through color change.
Project Details
Part 2
The Experiments
Part 3
Results
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