Team:NYC Wetware

From 2011.igem.org

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<b>Awarded Bronze Medal</b><br>
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<b>Won Best Human Practices Advance, Americas</b></br>
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<h4> Cloning and Evaluating Radiation Resistance Genes from E. coli and Deinococcus radiodurans </h4>
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<b>Featured on the <a href="http://area.autodesk.com/blogs/cory/maya_nyc_and_igem"> Autodesk Blog</a></b></br>
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<b>Check out our Presentation at the Jamboree. Enjoy!</b></br>
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<iframe src="http://player.vimeo.com/video/32398511?title=0&amp;byline=0&amp;portrait=0&amp;color=c9ff23" width="441" height="331" frameborder="0" webkitAllowFullScreen mozallowfullscreen allowFullScreen></iframe>
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<h4> Radiation-resistance? There's a Gene for That. </h4>
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Our iGEM squadron consists of students from the Dalton School, Hunter College, Columbia University, Yeshiva University, NYU-Poly, and Cornell University. Our advisors (and donated workspace) reside at Weill Cornell Medical College on the Upper East Side of Manhattan. Briefly, over the summer we will be investigating the genetic mechanisms for ionizing radiation resistance in Deinococcus radiodurans through genome sequencing, RNA-sequencing experiments, and high throughput cloning.  
Our iGEM squadron consists of students from the Dalton School, Hunter College, Columbia University, Yeshiva University, NYU-Poly, and Cornell University. Our advisors (and donated workspace) reside at Weill Cornell Medical College on the Upper East Side of Manhattan. Briefly, over the summer we will be investigating the genetic mechanisms for ionizing radiation resistance in Deinococcus radiodurans through genome sequencing, RNA-sequencing experiments, and high throughput cloning.  
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<h3>Our Approach</h3>
<h3>Our Approach</h3>
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We've been examining the literature on two approaches to explaining Deinococcus radiodurans' radioresisitance: <br>
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We've been examining the literature on different approaches to explaining Deinococcus radiodurans' radioresistance: <br>
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1. DNA Repair - Dr. John Battista's work has focused on the rapid DNA repair mechanisms of D. rad and their attendant proteins as the responsible parties for its extraordinary radioresistance. <p>
1. DNA Repair - Dr. John Battista's work has focused on the rapid DNA repair mechanisms of D. rad and their attendant proteins as the responsible parties for its extraordinary radioresistance. <p>
2. Cellular Metabolome - Dr. Michael Daly's research suggests that the higher Manganese to Iron Ratio in D. rad increases antioxidant properties in the cells and reduces damage from radiative events. <p>
2. Cellular Metabolome - Dr. Michael Daly's research suggests that the higher Manganese to Iron Ratio in D. rad increases antioxidant properties in the cells and reduces damage from radiative events. <p>
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3. Neutralization of superoxide radicals - the Superoxide Dismutase / Catalase system has been shown to neutralize damaging oxygen radicals in a variety of species from Humans to Wheat.
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Latest revision as of 19:12, 30 November 2011