http://2011.igem.org/wiki/index.php?title=Team:MIT&feed=atom&action=historyTeam:MIT - Revision history2024-03-29T07:25:46ZRevision history for this page on the wikiMediaWiki 1.16.0http://2011.igem.org/wiki/index.php?title=Team:MIT&diff=262563&oldid=prevJencheng at 04:03, 29 October 20112011-10-29T04:03:33Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p>Above is the result of a simulation run, starting with undifferentiated cells and ending with a pattern.</p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p>Above is the result of a simulation run, starting with undifferentiated cells and ending with a pattern.</p></div></td></tr>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline"><br></del><p>Specifically, for cell-cell signaling, we developed a modular juxtacrine platform, using Notch and Delta proteins. For intracellular information processing circuits, as a proof of concept, we build a 2-input AND gate. For cell-cell adhesion, the final output of our system, we used cadherin.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><p>Specifically, for cell-cell signaling, we developed a modular juxtacrine platform, using Notch and Delta proteins. For intracellular information processing circuits, as a proof of concept, we build a 2-input AND gate. For cell-cell adhesion, the final output of our system, we used cadherin.</div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Below is an animation depicting our project components. The cell-cell signaling of Notch-Delta interaction leads to the cleavage of the Notch intracellular domain, which enters the nucleus and after logic processing, expresses cadherins, which cause cells to adhere to similarly expressing cells.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Below is an animation depicting our project components. The cell-cell signaling of Notch-Delta interaction leads to the cleavage of the Notch intracellular domain, which enters the nucleus and after logic processing, expresses cadherins, which cause cells to adhere to similarly expressing cells.</div></td></tr>
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</table>Jenchenghttp://2011.igem.org/wiki/index.php?title=Team:MIT&diff=262558&oldid=prevJencheng at 04:03, 29 October 20112011-10-29T04:03:13Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Below is an animation depicting our project components. The cell-cell signaling of Notch-Delta interaction leads to the cleavage of the Notch intracellular domain, which enters the nucleus and after logic processing, expresses cadherins, which cause cells to adhere to similarly expressing cells.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>Below is an animation depicting our project components. The cell-cell signaling of Notch-Delta interaction leads to the cleavage of the Notch intracellular domain, which enters the nucleus and after logic processing, expresses cadherins, which cause cells to adhere to similarly expressing cells.</div></td></tr>
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</table>Jenchenghttp://2011.igem.org/wiki/index.php?title=Team:MIT&diff=262547&oldid=prevJencheng at 04:02, 29 October 20112011-10-29T04:02:31Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><br><p>Specifically, for cell-cell signaling, we developed a modular juxtacrine platform, using Notch and Delta proteins. For intracellular information processing circuits, as a proof of concept, we build a 2-input AND gate. For cell-cell adhesion, the final output of our system, we used cadherin.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><br><p>Specifically, for cell-cell signaling, we developed a modular juxtacrine platform, using Notch and Delta proteins. For intracellular information processing circuits, as a proof of concept, we build a 2-input AND gate. For cell-cell adhesion, the final output of our system, we used cadherin.</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Below is an animation depicting our project components. <del class="diffchange diffchange-inline">the </del>Notch-Delta interaction <del class="diffchange diffchange-inline">leading </del>to the cleavage of the Notch intracellular domain, which enters the nucleus and <del class="diffchange diffchange-inline">leads to the expression of </del>cadherins, which cause cells to adhere to similarly expressing cells.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Below is an animation depicting our project components. <ins class="diffchange diffchange-inline">The cell-cell signaling of </ins>Notch-Delta interaction <ins class="diffchange diffchange-inline">leads </ins>to the cleavage of the Notch intracellular domain, which enters the nucleus and <ins class="diffchange diffchange-inline">after logic processing, expresses </ins>cadherins, which cause cells to adhere to similarly expressing cells.</div></td></tr>
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</table>Jenchenghttp://2011.igem.org/wiki/index.php?title=Team:MIT&diff=262519&oldid=prevJencheng at 04:00, 29 October 20112011-10-29T04:00:12Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>We developed software tools to model the behavior of our system. Below is a sample of a simulation of cells with genetic circuits and how they differentiate.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div>We developed software tools to model the behavior of our system. Below is a sample of a simulation of cells with genetic circuits and how they differentiate.</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><div align="center"><iframe width="<del class="diffchange diffchange-inline">350</del>" height="<del class="diffchange diffchange-inline">262</del>" src="http://www.youtube.com/embed/dbz4VegsJOw?rel=0&amp;hd=1" frameborder="0" allowfullscreen></iframe></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><div align="center"><iframe width="<ins class="diffchange diffchange-inline">400</ins>" height="<ins class="diffchange diffchange-inline">300</ins>" src="http://www.youtube.com/embed/dbz4VegsJOw?rel=0&amp;hd=1" frameborder="0" allowfullscreen></iframe></div></td></tr>
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</table>Jenchenghttp://2011.igem.org/wiki/index.php?title=Team:MIT&diff=262511&oldid=prevJencheng at 03:59, 29 October 20112011-10-29T03:59:49Z<p></p>
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<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline">We developed software tools to model the behavior of our system. Below is a sample of a simulation of cells with genetic circuits and how they differentiate.</ins></div></td></tr>
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</table>Jenchenghttp://2011.igem.org/wiki/index.php?title=Team:MIT&diff=262478&oldid=prevJencheng at 03:58, 29 October 20112011-10-29T03:58:22Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p>Above is the result of a simulation run, starting with undifferentiated cells and ending with a pattern.</p></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p>Above is the result of a simulation run, starting with undifferentiated cells and ending with a pattern.</p></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><br><p>Specifically, we<del class="diffchange diffchange-inline">'ve </del>developed a modular juxtacrine <del class="diffchange diffchange-inline">cell-cell signaling </del>platform, using Notch and Delta proteins.</div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><br><p>Specifically<ins class="diffchange diffchange-inline">, for cell-cell signaling</ins>, we developed a modular juxtacrine platform, using Notch and Delta proteins. <ins class="diffchange diffchange-inline">For intracellular information processing circuits, as </ins>a <ins class="diffchange diffchange-inline">proof </ins>of <ins class="diffchange diffchange-inline">concept, we build a 2-input AND gate. For cell-cell adhesion, the final output </ins>of <ins class="diffchange diffchange-inline">our system, we used cadherin</ins>.</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><del class="diffchange diffchange-inline">Below(left) is </del>a <del class="diffchange diffchange-inline">simulation </del>of <del class="diffchange diffchange-inline">pattern formation </del>of <del class="diffchange diffchange-inline">cells with genetic circuits</del>. Below<del class="diffchange diffchange-inline">(right) </del>is an animation depicting <del class="diffchange diffchange-inline">showing </del>the Notch-Delta interaction leading to the cleavage of the Notch intracellular domain, which enters the nucleus and leads to the expression of cadherins, which cause cells to adhere to similarly expressing cells.</p></br></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Below is an animation depicting <ins class="diffchange diffchange-inline">our project components. </ins>the Notch-Delta interaction leading to the cleavage of the Notch intracellular domain, which enters the nucleus and leads to the expression of cadherins, which cause cells to adhere to similarly expressing cells.</div></td></tr>
<tr><td colspan="2"> </td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div></p></br></div></td></tr>
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</table>Jenchenghttp://2011.igem.org/wiki/index.php?title=Team:MIT&diff=262364&oldid=prevJencheng at 03:52, 29 October 20112011-10-29T03:52:10Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><br><p>Specifically, we've developed a modular juxtacrine cell-cell signaling platform, using Notch and Delta proteins.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><br><p>Specifically, we've developed a modular juxtacrine cell-cell signaling platform, using Notch and Delta proteins.</div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div>Below(left) is a simulation of pattern formation of cells with <del class="diffchange diffchange-inline">different </del>genetic circuits. Below(right) is an animation depicting showing the Notch-Delta interaction leading to the cleavage of the Notch intracellular domain, which enters the nucleus and leads to the expression of cadherins, which cause cells to adhere to similarly expressing cells.</p></br></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div>Below(left) is a simulation of pattern formation of cells with genetic circuits. Below(right) is an animation depicting showing the Notch-Delta interaction leading to the cleavage of the Notch intracellular domain, which enters the nucleus and leads to the expression of cadherins, which cause cells to adhere to similarly expressing cells.</p></br></div></td></tr>
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</table>Jenchenghttp://2011.igem.org/wiki/index.php?title=Team:MIT&diff=262338&oldid=prevJencheng at 03:51, 29 October 20112011-10-29T03:51:21Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><h3>Tissues by Design</h3></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><h3>Tissues by Design</h3></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><p>Our project focuses on <del class="diffchange diffchange-inline">genetically programming </del>tissue self-construction to achieve specific patterns of cell differentiation (initially with fluorescence, ultimately with cell fate regulators). To accomplish we focused on three components: cell-cell communication pathways, intracellular information processing circuits, and cell-cell adhesion. Through engineered control of these mechanisms, we are investigating how programmed local rules of interactions between cells can lead to the emergence of desired global patternings.</p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><p>Our project focuses on tissue self-construction to achieve specific patterns of cell differentiation (initially with fluorescence, ultimately with cell fate regulators) <ins class="diffchange diffchange-inline">with genetic circuits</ins>. To accomplish <ins class="diffchange diffchange-inline">this, </ins>we focused on three components: cell-cell communication pathways, intracellular information processing circuits, and cell-cell adhesion. Through engineered control of these mechanisms, we are investigating how programmed local rules of interactions between cells can lead to the emergence of desired global patternings.</p></div></td></tr>
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</table>Jenchenghttp://2011.igem.org/wiki/index.php?title=Team:MIT&diff=262311&oldid=prevJencheng at 03:50, 29 October 20112011-10-29T03:50:05Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p><img src="https://static.igem.org/mediawiki/2011/5/51/Simulation.jpg" style="max-width:800px; margin-right:10px;"/></p></br></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p><img src="https://static.igem.org/mediawiki/2011/5/51/Simulation.jpg" style="max-width:800px; margin-right:10px;"/></p></br></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><p><del class="diffchange diffchange-inline">This </del>is the result of a simulation run, starting with undifferentiated cells and ending with a pattern.</p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><p><ins class="diffchange diffchange-inline">Above </ins>is the result of a simulation run, starting with undifferentiated cells and ending with a pattern.</p></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><br><p>Specifically, we've developed a modular juxtacrine cell-cell signaling platform, using Notch and Delta proteins.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><br><p>Specifically, we've developed a modular juxtacrine cell-cell signaling platform, using Notch and Delta proteins.</div></td></tr>
</table>Jenchenghttp://2011.igem.org/wiki/index.php?title=Team:MIT&diff=262303&oldid=prevJencheng at 03:49, 29 October 20112011-10-29T03:49:39Z<p></p>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><h3>Tissues by Design</h3></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><h3>Tissues by Design</h3></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div><p>Our project focuses on genetically programming tissue self-construction to achieve specific patterns of cell differentiation (initially with fluorescence, ultimately with cell fate regulators). <del class="diffchange diffchange-inline">This is accomplished through our synthetic genetic circuits, which incorporate our engineered </del>cell-cell communication pathways, intracellular information processing circuits, and cell-cell adhesion. Through engineered control of these mechanisms, we are investigating how programmed local rules of interactions between cells can lead to the emergence of desired global patternings.</p></div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><p>Our project focuses on genetically programming tissue self-construction to achieve specific patterns of cell differentiation (initially with fluorescence, ultimately with cell fate regulators). <ins class="diffchange diffchange-inline">To accomplish we focused on three components: </ins>cell-cell communication pathways, intracellular information processing circuits, and cell-cell adhesion. Through engineered control of these mechanisms, we are investigating how programmed local rules of interactions between cells can lead to the emergence of desired global patternings.</p></div></td></tr>
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<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p><img src="https://static.igem.org/mediawiki/2011/5/51/Simulation.jpg" style="max-width:800px; margin-right:10px;"/></p></br></div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><p><img src="https://static.igem.org/mediawiki/2011/5/51/Simulation.jpg" style="max-width:800px; margin-right:10px;"/></p></br></div></td></tr>
<tr><td class='diff-marker'>-</td><td style="background: #ffa; color:black; font-size: smaller;"><div> </div></td><td class='diff-marker'>+</td><td style="background: #cfc; color:black; font-size: smaller;"><div><ins class="diffchange diffchange-inline"><p>This is the result of a simulation run, starting with undifferentiated cells and ending with a pattern.</p></ins></div></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"></td></tr>
<tr><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><br><p>Specifically, we've developed a modular juxtacrine cell-cell signaling platform, using Notch and Delta proteins.</div></td><td class='diff-marker'> </td><td style="background: #eee; color:black; font-size: smaller;"><div><br><p>Specifically, we've developed a modular juxtacrine cell-cell signaling platform, using Notch and Delta proteins.</div></td></tr>
</table>Jencheng