Team:Freiburg/Modelling

From 2011.igem.org

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(Modelling: Rational protein design)
(Modelling: Rational protein design)
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The second milestone in the generation of the idea came up in a lecture of Prof. Martin, about Nickel allergy. He found a mutation in the TLR-4 receptor that indroduces Histidines in the LRR motif of the protein, which are capable of binding nickel and thus forming complexes of receptors on the cell surface of immune cells, triggering the inflammatory reaction.  
The second milestone in the generation of the idea came up in a lecture of Prof. Martin, about Nickel allergy. He found a mutation in the TLR-4 receptor that indroduces Histidines in the LRR motif of the protein, which are capable of binding nickel and thus forming complexes of receptors on the cell surface of immune cells, triggering the inflammatory reaction.  
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[[File:Freiburg11Modelling1.png|thumb|750px]]
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[[File:Freiburg11Modelling1.png|frame|750px|caption]]
This was the necessary clue that gave answer to the question.
This was the necessary clue that gave answer to the question.

Revision as of 15:45, 20 September 2011


This is the wiki page
of the Freiburger student
team competing for iGEM 2011.
Thank you for your interest!